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Salary: USD 270,000 - 320,000 / annual
COMPASS Pathways plc (Nasdaq: CMPS) is a biotechnology company dedicated to unlocking new treatment options in mental health care. The company is headquartered in London with a U.S. office in New Jersey. The company is developing COMP360, a proprietary investigational synthetic psilocybin treatment under evaluation for treatment-resistant depression (TRD) and post-traumatic stress disorder (PTSD). COMP360 has Breakthrough Therapy designation from the FDA and Innovative Licensing and Access Pathway (ILAP) designation in the UK for TRD.
The Medical Director, Medical Affairs will serve as a subject matter expert representing professional medical expertise within the Medical Affairs function, with an initial focus on TRD and investigational psychedelic therapeutics. This individual will provide clinical perspective, medical judgment, and thought partnership to Medical Affairs leadership and functional teams.
Key responsibilities include:
**Therapeutic Area Expertise and Medical Guidance:** Serve as a medical subject matter expert in TRD, interventional psychiatry, and emerging psychiatric treatments. Provide clinical insights and recommendations to inform Medical Affairs priorities. Critically evaluate clinical trial results, scientific literature, and evolving treatment guidelines. Partner with Scientific Communications, Medical Information, Medical Education, and Field Medical leadership to ensure clinical relevance across Medical Affairs activities. Identify emerging developments and clinical practice considerations that may inform future priorities. Provide medical expertise to support future therapeutic indications and pipeline opportunities.
**Evidence Generation and Research:** Lead the development of Medical Affairs research proposals and evidence-generation initiatives aligned with organizational scientific priorities. Collaborate with Clinical Development, Clinical Sciences, Biostatistics, HEOR, and other stakeholders to develop rigorous research concepts, protocols, and analysis plans. Provide medical oversight and direction for Medical Affairs-sponsored research, including real-world evidence studies and observational research. Support evaluation of investigator-initiated research proposals and external research collaborations. Contribute to interpretation and dissemination of research findings through publications, congress presentations, and other channels.
**External Scientific Engagement:** Lead or contribute to advisory boards, expert consultations, and other external engagements to identify unmet needs and evidence gaps. Represent Medical Affairs in scientific discussions at medical congresses and professional society meetings. Engage external experts to understand emerging clinical evidence and treatment practices. Collaborate with Field Medical leadership to support scientific exchange priorities and therapeutic area education. Support external research collaborations that advance understanding of TRD and emerging treatment approaches.
**Scientific Communications and Medical Review:** Provide medical expertise to support development of publications, scientific presentations, medical education materials, and Medical Information resources. Collaborate with Scientific Communications and Medical Information leadership to ensure materials accurately reflect available evidence. Serve as a Medical Affairs representative on the Medical, Legal, and Regulatory (MLR) review committee. Evaluate scientific claims, clinical data presentations, and medical content for accuracy, balance, and clinical relevance. Collaborate with Regulatory, Legal, Compliance, and other stakeholders to support appropriate scientific communication. Provide medical expertise to support responses to complex scientific inquiries from healthcare professionals.
**Cross-Functional Collaboration:** Serve as a key medical partner to Clinical Development, Clinical Sciences, Regulatory, Safety, HEOR, and other functions. Facilitate exchange of clinical insights between Medical Affairs and internal stakeholders. Contribute to cross-functional discussions involving clinical evidence, treatment implementation, safety considerations, and future research opportunities. Support alignment of Medical Affairs activities with broader clinical development and organizational priorities.
Reports to: Executive Director, Medical Affairs.
**Requirements:**
The successful candidate must bring deep expertise in psychiatry, the ability to critically analyze emerging evidence, and established relationships within the medical and scientific community. This individual should be proactive in identifying important clinical knowledge gaps, recommending approaches to addressing them, and taking an active role in developing and advancing research initiatives that inform clinical practice.
