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Cellanome is seeking a Head of Systems Engineering to lead the systems engineering discipline for the R3200 instrument platform. This is a hands-on leadership role reporting to the SVP of Product Development, responsible for owning system architecture, technical budgets, and system-level verification and validation from current production through next-generation designs.
Key responsibilities include:
• Create and own system models, define technical budgets, and guide system/subsystem architecture decisions and tradeoffs
• Develop system and subsystem-level interfaces, test strategies, and verification plans
• Drive understanding of complex integrated systems combining hardware, consumables, chemistry, assays, bioinformatics, and cell biology
• Own system-level verification and validation strategy, including protocol definition, execution oversight, and documentation for phase-gate reviews
• Drive design transfer to manufacturing, partnering with Operations and contract manufacturers through pilot builds to volume production
• Partner with technical and executive leadership to prioritize R&D initiatives and guide product roadmaps
• Hold make-versus-buy authority for subsystem development; select and manage external design houses and specialty suppliers
• Define statements of work, technical acceptance criteria, and milestone structures for third-party development
• Own bill of materials cost targets and drive cost reduction roadmap through component consolidation and design simplification
• Own system requirements architecture with full traceability from user needs through component requirements to verification evidence
• Own system-level risk management including FMEA, hazard analysis, and risk mitigation tracking
• Establish design review cadence and standards across hardware, consumables, assay, software, and analysis contributions
• Define systems engineering metrics for stage-gate reviews: requirement stability, verification coverage, open issues, and specification margin
• Set and own reliability targets (MTBF, uptime, MTTR) and develop reliability growth plans including accelerated life testing and HALT/HASS
• Own system-level failure mode catalog and drive root cause analysis for field failures
• Own system-level control strategy for performance specification across instruments and time, including calibration and requalification criteria
• Travel up to 25% of working time as needed
The ideal candidate will define how the systems engineering discipline operates, expand the team, and be accountable for platform specifications meeting customer needs.
