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VP, Head of Drug Discovery

Relay Therapeutics - Cambridge, MA, United States - In-office - posted 2026-07-28

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Relay Therapeutics seeks an exceptional scientific leader to oversee integrated Medicinal Chemistry, Computational Chemistry, Cheminformatics, and Drug Metabolism & Pharmacokinetics (DMPK) organizations. This VP-level role is responsible for driving the discovery and optimization of transformative small molecule therapeutics by building a highly collaborative, data-driven discovery engine that combines deep scientific expertise with modern computational approaches. The successful candidate will be a recognized leader in small molecule drug discovery with a proven track record of advancing programs from hit identification through IND filing. They will serve as a key member of research leadership, fostering an environment where all disciplines work as a unified team to rapidly test hypotheses, learn from experimental data, and deliver differentiated medicines. Key responsibilities include leading and integrating the Medicinal Chemistry, Computational Chemistry, Cheminformatics, and DMPK organizations to create a highly effective, collaborative drug discovery engine. The role requires defining and executing scientific strategies that enable rapid hypothesis testing and learning cycles. The ideal candidate is energized by solving complex scientific problems, embracing emerging technologies, and building high-performing scientific organizations within a fast-paced biotechnology environment. Relay's discovery strategy combines hypothesis-driven biology, medicinal chemistry, computational chemistry, structural biology, and DMPK to iteratively design, test, and refine molecules based on quantitative experimental evidence. By coupling deep scientific expertise with state-of-the-art computational technologies, the organization aims to accelerate learning, improve decision quality, and deliver differentiated therapies for patients with serious diseases.

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