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Salary: USD 75,000 - 100,000 / annual
NewLimit is a biotechnology company developing medicines to treat age-related diseases by reprogramming the epigenome. The company uses functional genomics, pooled perturbation screening, and machine learning to understand epigenetic aging and disease at unprecedented scale.
The Single Cell Technology and Assay Development group is seeking a Senior/Research Associate to develop and apply advanced molecular and bioanalytical technologies supporting therapeutic discovery and development. This role spans single-cell genomics, biomarker development, biodistribution, and bioanalytical method development.
Key responsibilities include:
- Measuring biodistribution, pharmacokinetics, and efficacy of reprogramming medicines using traditional molecular assays and frontier genomics methods
- Designing and executing experiments involving isolation, culture, and processing of cells, tissues, and organs for molecular profiling
- Collaborating with the Epigenetic Editing team to perform large-scale single-cell perturbation experiments with custom chemistries
- Performing state-of-the-art single-cell profiling experiments to map epigenetic features of age-related disease and evaluate interventions
REQUIREMENTS:
- Bachelor's degree in cell biology, molecular biology, or related natural science, OR equivalent industry experience
- 2+ years of work experience in a cell or molecular biology laboratory (academic or industry)
- Experience with standard molecular biology workflows (nucleic acid extraction, qPCR, ELISA, NGS library construction, library quantification and QC)
- Experience with necropsy, organ/tissue collection, primary tissue dissociation, mammalian cell culture, and sample processing (single-cell suspension preparation, nuclei isolation, fixation)
NICE TO HAVE:
- Experience with in vivo animal handling
- Experience with single-cell genomics methods (10x Genomics, Parse Bio, Perturb-seq/CROProp-seq or similar)
- Experience troubleshooting or optimizing NGS workflows
- Experience with flow cytometry sorting for single-cell preparations
