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Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. The company combines expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate RNA therapeutic development for new tissues, addressing a major unmet need in the industry.
You will lead molecular biology strategy and execution for studies characterizing pharmacokinetics, pharmacodynamics, biodistribution, target engagement, and activity of RNA therapeutic candidates. This is a hands-on scientific leadership role that owns studies from experimental design through data interpretation, integrating molecular readouts with in vivo and program data to guide development decisions.
SCIENTIFIC RESPONSIBILITIES:
- Design and lead quantitative molecular biology studies supporting PK/PD, biodistribution, target engagement, and gene expression assessments
- Develop, optimize, qualify, and oversee workflows for RNA/DNA extraction, cDNA synthesis, RT-qPCR, qPCR, ddPCR, and related molecular assays
- Establish robust sample-processing workflows across cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, and RNase-free handling
- Translate program questions into study strategies with appropriate controls, acceptance criteria, replication, and timelines
- Analyze and integrate complex datasets including relative/absolute quantification, assay performance metrics, and relationships among molecular, exposure, and efficacy readouts
- Lead troubleshooting and root-cause investigations for assay and instrument performance; implement durable improvements
- Establish and maintain SOPs, assay qualification summaries, data analysis templates, and training materials
- Ensure accurate, real-time documentation in electronic lab notebooks
- Coordinate cross-functionally to align sample generation, handling, analysis, and reporting with study objectives and timelines
- Present data with clear context, controls, conclusions, and recommendations to guide experimental plans and program decisions
LEADERSHIP RESPONSIBILITIES:
- Lead quantitative molecular biology strategy across one or more pharmacology programs
- Own molecular assay platforms end-to-end, including capability building, performance tracking, risk identification, and continuous improvement
- Identify and implement new technologies, analytical approaches, and external capabilities
- Mentor scientists and research associates, providing technical guidance and maintaining high standards for rigor and reproducibility
- Serve as scientific leader across functions and external collaborations, integrating molecular and in vivo evidence into program strategy
REQUIREMENTS:
- PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, Bioengineering, or related field, or equivalent advanced training and relevant industry experience
- Deep hands-on experience with quantitative PCR methods and molecular assay development, including work with complex tissue or biofluid samples
- Demonstrated ability to design pharmacology studies, interpret PK/PD readouts, and integrate molecular results with cross-functional datasets
- Experience with RNA therapeutic development including preclinical pharmacology data preparation and presentation for scientific and regulatory interactions
- Ability to work on site in Alameda, California
