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Asimov is a synthetic biology startup developing a mammalian synthetic biology platform to enable the design and manufacture of next-generation therapeutics. We are seeking a Senior Scientist to lead our Lentiviral Vector Cell Line Development team in Boston, MA.
In this role, you will set and steer the scientific roadmap for the Lentiviral Vector cell line development (CLD) platform while performing hands-on experimentation. You will drive the creation of stable producer cell lines for lentiviral vector therapeutics, including transfection, pool generation, single cell cloning, clone screening and characterization, and cell banking using state-of-the-art equipment.
Key responsibilities include:
- Setting and steering the scientific roadmap for the Lentiviral Vector CLD platform
- Performing lentiviral vector stable producer cell line development processes
- Serving as the primary technical contact on customer and commercial projects, partnering with the commercial team to present platform capabilities and translate customer requirements into executable project plans
- Providing technical leadership and mentorship to scientists on the team, including managing direct report(s) and setting high standards for experimental design, data analysis, and record-keeping
- Representing Lentiviral Vector CLD on cross-functional and leadership-facing project teams, making strategic decisions and communicating progress, risk, and plans
- Supporting innovation through development of novel workflows and applications
- Supporting research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency, and cell targeting
- Working effectively as part of a cross-functional team in collaboration with Synthetic Biology and Process Development teams
- Designing experiments, analyzing data, troubleshooting, and maintaining detailed records
- Representing Asimov's science externally through publications and presentations at leading industry conferences
Requirements:
- M.S. or PhD in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field
- 7+ years of hands-on experience in biopharma, including 4+ years focused on lentiviral vector producer or packaging cell line development in support of GLP or GMP production of cell or gene therapies
- 2+ years of experience managing direct report(s) and providing technical guidance
- Proven track record balancing hands-on bench leadership with big-picture platform strategy and roadmapping
- Experience communicating technical work to external stakeholders and translating their needs into technical plans
- Demonstrated ability to communicate scientific work externally, evidenced by publications, patents, and/or conference presentations
- Strong written and verbal communication skills
Highly desired:
- Experience with downstream purification and PQ assessment of lentiviral vectors
- T-cell transduction assay experience
- Viral genome engineering and/or host cell genome engineering related to virus production or producer cell line technologies
- Experience with process development at Ambr or benchtop bioreactor scale
- Comfort working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights
