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Salary: USD 290,000 - 380,000 / annual
Alector is a biotech company developing therapies that harness the immune system to combat neurodegeneration. As Senior Director of Clinical Development, you will serve as the senior clinical development physician and key clinical leader for AL137 as it enters Phase 1 clinical trials.
You will own the clinical and medical strategy for Phase 1 and help shape the program's path toward later-stage development. This includes integrating emerging clinical, translational, safety, and biomarker data into rigorous, patient-centered decisions. You will provide medical leadership for protocol design and execution, eligibility and safety considerations, dose escalation, clinical data review, and interpretation of emerging results while partnering closely with Clinical Operations and investigators.
As the internal physician expert for AL137, you will serve as Alector's clinical voice, providing clear clinical perspectives to program teams and senior leadership. You will build productive relationships with investigators, external experts, partners, and regulatory authorities. You will partner across Biometrics, Translational Medicine, Safety, Regulatory, and other functions to define evidence needed for critical development decisions and communicate the clinical meaning of emerging data.
A key aspect of this role is identifying practical ways to use AI and emerging technologies to accelerate analysis, improve decision-making, streamline clinical-development work, and conserve valuable time and resources.
Required: M.D. (preferred) or Ph.D. in Neuroscience, Neurobiology, or equivalent. 10+ years leading clinical development in biotech or pharma, with essential experience taking programs through early clinical development. Drug development experience in neurodegenerative disease is required. Strong knowledge of clinical trial design, medical monitoring, clinical data interpretation, benefit-risk assessment, and regulatory requirements. Experience designing and executing first-in-human, Phase 1, and Phase 2 studies, including dose escalation and interpretation of early safety, pharmacokinetic, pharmacodynamic, and biomarker data. Experience working with regulators and contributing clinical content to regulatory submissions. Demonstrated ability to exercise independent medical judgment and provide clinical leadership within cross-functional teams. Ability to translate complex scientific and clinical information into clear recommendations. Active user of large language models with strong interest in evolving AI technologies. Experience in small or rapidly evolving biotech organizations.
