SlipstreamJobs tracks this role from the company's public career site. Apply directly on the employer's site.
Salary: USD 129,000 - 151,000 / annual
Vaxcyte is a clinical-stage vaccine innovation company developing high-fidelity vaccines to protect against bacterial diseases including invasive pneumococcal disease, Group A Strep, and Shigella.
You will join the Drug Product Development team as a hands-on scientist responsible for designing, developing, programming, and deploying automated analytical methods on Hamilton liquid handling platforms. Your primary focus will be automating the company's multiplexed immunoassay (MSD) suite and translating manual bench assays into robust, reproducible automated workflows.
Key responsibilities include:
- Design, program, and deploy automated analytical methods on Hamilton VENUS platforms, serving as the technical lead for building, testing, validating, and maintaining automated assay workflows
- Program, script, and troubleshoot automated methods in Hamilton VENUS software, independently resolving hardware, liquid-handling, and system integration issues
- Execute routine and non-routine analysis of internal release, development, and stability samples using various analytical techniques
- Automate, optimize, and continuously improve the MSD assay suite, including transferring manual assays to automated platforms and troubleshooting assay performance
- Support analytical comparability assessments including study design, execution, statistical analysis, and reporting
- Contribute to method development, qualification, and technology transfer activities with external laboratories and CMOs
- Author and review technical documentation including protocols, SOPs, automated method files, reports, and study plans
- Support cross-functional collaboration with Drug Product Development, Formulation, Analytical Development, Quality, and external partners
This is a predominantly lab-based role requiring strong scientific judgment, independence in experimental execution, rigor in data analysis, and meticulous record keeping. You will manage multiple priorities in a fast-paced development environment with minimum 4 days per week onsite.
REQUIREMENTS:
- PhD, MS, or Bachelor's degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or related scientific discipline. PhD with 0-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience. Other combinations of education and experience may be considered.
- Hands-on experience developing and programming methods on automated liquid handling platforms, with Hamilton VENUS software strongly preferred (Tecan, Beckman, or comparable systems considered)
- Demonstrated programming and scripting ability (Hamilton VENUS, Python, VBA, or equivalent) to build automated workflows, integrate instrumentation, and support data handling
- Hands-on experience developing, optimizing, and executing ELISA or multiplex immunoassays (MSD preferred) with ability to troubleshoot assay performance
- Experience supporting or leading method transfer, method bridging, or comparability assessments including study design and statistical analysis
- Familiarity with plate-based assays (Lowry, BCA, etc.) and multiplexed immunoassays (MSD)
- Experience analyzing and visualizing assay data using Excel, Prism, or equivalent statistical/data analysis platforms
- Experience authoring analytical technical documentation including protocols, SOPs, reports, and maintaining electronic laboratory notebooks (eLN)
- Strong organizational skills and ability to manage multiple projects with shifting priorities
- Strong interpersonal and communication skills with ability to collaborate across teams and mentor junior analysts
- Detail-oriented with high scientific rigor and excellence in data integrity and record keeping
