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Iambic Therapeutics, a clinical-stage AI-driven drug discovery company based in San Diego, is seeking a Senior Associate Scientist to join its Chemistry team. This is a hands-on laboratory role focused on medicinal chemistry and organic synthesis within a dynamic, cross-functional environment.
You will design, synthesize, purify, and characterize chemical compounds at 10 mg–5 g scale using modern analytical techniques including LCMS, HPLC, and NMR. You will employ both individual and automated parallel synthesis approaches, identify and optimize reaction conditions using screening kits, and collaborate with high-throughput experimentation teams. The role involves analyzing biological and ADME-PK data using cheminformatics tools, partnering with computational chemists to leverage machine learning insights for the design–make–test cycle, and presenting results to project teams and senior leadership.
You will work across all stages of discovery, from hit identification through lead optimization to candidate selection, collaborating with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers. The position requires a demonstrated "drug hunter" mindset and strong technical expertise in organic synthesis, catalysis, and medicinal chemistry.
Iambic's platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed across multiple target classes and mechanisms of action. The company operates from a brand-new state-of-the-art facility in San Diego with onsite gym and dining.
REQUIREMENTS:
- BS in Chemistry with 5+ years pharma/biotech experience, OR MS in Chemistry with 3+ years pharma/biotech experience
- Proven skills in multi-step organic synthesis, reaction optimization, and SAR analysis
- Strong scientific presentation abilities
- Ability to thrive in a fast-paced, highly collaborative research environment
- Availability to work onsite in San Diego
PREFERRED:
- Prior exposure to high-throughput experimentation
- Familiarity with ADME-PK principles
- 5+ years contributing to drug discovery projects
- Experience with molecular modeling and structure-based drug design
