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Iambic Therapeutics, a clinical-stage biotech company founded in 2020, is seeking an experienced Principal Scientist in Medicinal Chemistry to join its San Diego headquarters. The company develops novel medicines using an AI-driven discovery and development platform, with a track record of advancing drug candidates to human clinical trials with unprecedented speed across multiple target classes and mechanisms of action.
In this role, you will devise strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis-driven design principles. You will execute high-quality ideas by employing modern organic chemistry transformations, synthetic methods, parallel experimentation, and innovative techniques. Key responsibilities include:
- Developing and executing medicinal chemistry strategies for lead identification and optimization
- Conducting advanced lead compound optimization for potency, selectivity, ADME, and PK properties
- Collaborating closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other research functions
- Influencing and leveraging computational methods, automated synthesis, and high-throughput experimentation capabilities
- Working with AI/ML teams to develop and implement predictive models for molecular design
- Communicating project updates clearly to the broader team and stakeholders
- Fostering a culture of scientific excellence, innovation, and teamwork within the Chemistry research group
The ideal candidate is passionate about solving medicinal chemistry challenges and proactively interfaces with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
QUALIFICATIONS:
- BS, MS, or PhD in chemistry with focus on synthetic organic chemistry
- Small molecule drug discovery experience in biotechnology or pharmaceutical setting: BS with 15+ years, MS with 12+ years, or PhD with 8+ years
- Proven track record advancing programs from leads to advanced candidates
- Extensive experience in lead compound optimization for potency, selectivity, ADME, and PK
- Expert-level knowledge of modern synthetic organic chemistry approaches, demonstrated through publications and patents
- Practical experience with target protein degradation and associated modalities (molecular glues, PROTACS)
- Ability to integrate multiple R&D disciplines into successful strategic project plans
- Required experience working with computational chemists as part of project teams in drug target design
- Strong interpersonal, communication, time management, and leadership skills
- Creative problem-solving and stakeholder relationship management capabilities
