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Prellis Biologics is seeking a Principal Associate Scientist or Scientist to join the High-Throughput Discovery group. The company uses proprietary 3D printing technology to create human lymph node organoids, enabling rapid discovery of human antibody therapeutic candidates for obesity, inflammation, immunology, and oncology applications.
In this role, you will drive end-to-end primary cell screening and high-throughput antibody discovery. Key responsibilities include:
• Isolate and enrich B cells and plasma cells from immunization campaigns, leveraging single-cell platforms (10x Genomics, microfluidics) to identify antigen-specific B cells
• Develop, execute, and optimize primary screens using ELISA and cell-based assays (iQue) to characterize antibodies expressed by mammalian cells
• Scale high-throughput screening strategies for binder discovery from Prellis's proprietary discovery platforms
• Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities
• Develop and optimize automated workflows to ensure data quality, reproducibility, and process efficiency
• Partner cross-functionally with Antibody Protein Engineering, Discovery, Production, and Data Science/AI-ML teams to analyze and interpret screening data
• Independently manage multiple projects with timely delivery of high-quality data
• Maintain accurate ELN documentation and communicate results clearly to internal and external audiences
This is a hands-on role within a dynamic, cross-functional team with significant opportunities for growth and expanded responsibilities.
REQUIREMENTS:
For Principal Associate Scientist level: BSc/MSc in a related field with 4+ years of direct relevant industry experience.
For Scientist level: PhD in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or related field (postdoctoral or industry experience welcome).
Core requirements (both levels):
• Hands-on experience developing primary screens using ELISA and on-cell or cell-based assays (iQue or comparable)
• Experience isolating and enriching B cells or plasma cells, including hands-on operation of a FACS sorter (Sony MA900 preferred, or comparable)
• Strong competence handling primary cells (primary lymphocytes, PBMCs, or comparable), including aseptic technique, viability management, and downstream sample handling
• Proficiency in core molecular biology techniques (cloning, PCR), mammalian cell culture, and transient transfection
• Strong analytical skills and ability to troubleshoot complex experimental issues independently
• Ability to analyze experimental data using standard visualization and statistical tools (GraphPad Prism, Excel, or comparable); familiarity with R or Python is a plus but not required
• Excellent written and verbal communication skills; ability to present scientific findings clearly to diverse audiences
• Enthusiastic team player, effective across interdisciplinary teams
Bonus qualifications:
• Background in B cell immunology or antibody biology
• Experience with high-throughput antibody display technologies (e.g., mammalian display)
• Experience with microfluidics-based single-cell screening platforms
• Familiarity with laboratory automation platforms (Biomek, Hamilton, Tecan, or comparable)
