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Executive Operations, CEO Office

Pathos - New York, NY, USA - In-office - posted 2026-09-09

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Pathos is an AI-driven biotech company redesigning drug development from first principles. The company operates with a lean, high-leverage model: small teams of 3-5 subject matter experts, each commanding 30-50 AI agents to execute work that traditionally required dozens of people. With four clinical-stage oncology programs, a ~$3 billion valuation, and partnerships with top-five pharma companies, Pathos is well-capitalized and actively fundraising. This Executive Operations role owns the foundational logistics of the CEO's office—calendar management, travel coordination, and daily operations. However, the scope extends far beyond traditional executive assistant duties. You will be the operational backbone supporting a CEO whose week spans investor meetings, board sessions, pharma partner discussions, and clinical milestone reviews. The role requires orchestrating complex, high-stakes interactions across clinical, regulatory, finance, and business development functions. Key responsibilities include: managing the CEO's calendar and travel logistics; coordinating board meetings and investor presentations; supporting fundraising activities (Series E); facilitating pharma partnership discussions; ensuring seamless communication across clinical programs and internal teams; and identifying operational inefficiencies that compound over time. You will work directly with the CEO and leadership team to anticipate needs, solve problems at scale, and enable faster decision-making. The ideal candidate is an experienced operator with a track record of building and shipping in high-stakes environments. You thrive in ambiguity, can specify what needs to happen and orchestrate execution, and make high-judgment calls that compound. Deep expertise in executive operations, startup scaling, or biotech/pharma environments is valuable. You are comfortable with AI-augmented workflows and can leverage tools to multiply your impact. This is not a traditional administrative role—it is a strategic operations position that directly influences company velocity and CEO effectiveness.

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