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BioAge Labs is seeking an experienced Director of Drug Metabolism and Pharmacokinetics (DMPK) to lead the company's DMPK and translational pharmacology function. Reporting to the VP of Non-Clinical Development, this role is fully remote and open to candidates anywhere in the continental US.
In this position, you will lead DMPK and translational pharmacology strategy across BioAge's pipeline, supporting programs from lead optimization through IND-enabling studies and clinical development. Key responsibilities include developing integrated DMPK strategies to optimize absorption, distribution, metabolism, and excretion (ADME), exposure, tissue distribution, and pharmacokinetic/pharmacodynamic (PK/PD) relationships. You will design, oversee, and interpret in vitro and in vivo DMPK, ADME, metabolite identification, and bioanalytical studies to enable informed candidate selection and progression decisions.
You will partner closely with Medicinal Chemistry, Discovery Biology, Biomarkers, Toxicology, Clinical Pharmacology, and Clinical Development teams to integrate DMPK data into overall program strategy. The role involves designing and directing quantitative PK/PD, exposure-response, and PBPK/population-PK modeling that integrates nonclinical and clinical data, driving mechanism-based dose selection and model-informed drug development.
Additional responsibilities include providing scientific leadership for first-in-human dose projections, clinical pharmacology strategy, and translational plans bridging preclinical findings to clinical development. You will identify and address DMPK risks and optimization opportunities, including drug-drug interaction potential, metabolite characterization, formulation considerations, and species translation. The role also involves selecting, managing, and overseeing external CROs and strategic partners conducting DMPK and bioanalytical studies, ensuring high scientific quality, timely execution, and regulatory compliance. You will author and review DMPK and translational pharmacology sections of regulatory submissions and scientific communications.
