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Salary: USD 110,000 - 120,000 / annual
Arbor Biotechnologies, a clinical-stage gene editing company based in Cambridge, MA, is seeking an Associate Scientist to support protein engineering campaigns for next-generation genome editing tools. The company is advancing a portfolio of first-in-class genomic medicines addressing serious diseases, with a CNS pipeline prioritizing ALS targets and a co-developed clinical program (ABO-101) for primary hyperoxaluria type 1 treatment.
In this role, you will independently plan, execute, optimize, and troubleshoot experiments supporting protein engineering campaigns. Key responsibilities include:
• Design, generate, and evaluate protein mutants and variants, recommending experimental approaches, controls, and follow-up studies
• Execute cell-based screening workflows using transient transfection, nucleofection, and transduction in dividing and non-dividing cell models
• Design, package, and evaluate AAVs for protein variant testing, including troubleshooting production, delivery, and performance issues
• Synthesize, purify, characterize, and test IVT-generated mRNA, including troubleshooting quality, yield, and cellular delivery
• Prepare sequencing libraries and analyze experimental outputs to assess editing outcomes and variant performance
• Interpret data, summarize conclusions, and make recommendations that inform next-step experiments and campaign decisions
• Maintain high-quality documentation and prepare clear data packages for cross-functional review
• Collaborate with upstream design and downstream testing teams on experimental planning, prioritization, and handoff
• Present results and contribute scientific input to project planning and experimental strategy
You are detail-oriented, motivated, and possess a team-first mentality with a willingness to learn and flexibility in approach.
REQUIREMENTS:
• Bachelor's degree in biology, biochemistry, molecular biology, or related discipline with minimum 8 years of related experience, OR Master's degree with minimum 6 years of relevant experience; industry experience preferred
• Demonstrated ability to independently execute and optimize complex molecular biology, cell-based assay, and protein variant evaluation workflows
• Hands-on experience with AAV production and testing, including vector design, packaging, assay execution, and troubleshooting of production or performance issues
• Hands-on experience with IVT mRNA synthesis, purification, characterization, and cellular delivery, including troubleshooting quality, yield, and transfection/nucleofection performance
• Strong tissue culture experience, including transient transfection, nucleofection, or transduction in dividing and/or non-dividing cell types; experience with primary cells is a plus
• Experience contributing to experimental design, data interpretation, and recommendation of next-step studies
• Ability to manage multiple experiments or workstreams with general guidance and communicate results clearly to scientific stakeholders
• Experience with CRISPR gene editing technologies is a plus
• Familiarity with Illumina sequencing workflows is a plus
