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Salary: USD 185,500 - 344,500 / annual
DTX Pharma, a Novartis Company, seeks a Therapeutic Area Biomarker Director to lead the Cardiovascular and Metabolism (CVM) disease area biomarker strategy and matrix team. This Director-level role is responsible for developing and implementing fit-for-purpose biomarker strategies across the CVM portfolio, with a focus on heart failure, atherosclerosis, obesity, and atrial fibrillation indications.
Key responsibilities include:
- Delivering clinical project and disease biomarker strategies across early through late-phase development within the CVM portfolio
- Leading a dedicated matrixed group of Subject Matter Experts and project team representatives to develop biomarker strategies across the Research-Development-Commercial continuum
- Representing Biomarker Development on CVM Disease Area Decision Boards to identify and drive cardiovascular and metabolic disease mechanistic biology and precision medicine approaches
- Leading strategic translational data working groups to integrate and analyze large-scale patient multi-modal datasets (omics, imaging, digital) to identify new indications, endpoints, and responsive patient subpopulations
- Representing biomarker line functions in Therapeutic Area Line Function committees for clinical protocol development
- Staying current on clinical, disease, biology, and scientific literature and competitor data
- Collaborating with the global BMD organization (150+ associates) across genetics, genomics, molecular/cellular biology, digital devices, imaging, and data sciences
- Designing and presenting RDC biomarker strategy for transitioning and mature assets
Required qualifications:
- MD, MD/PhD, or PhD degree plus additional PhD/postdoc or equivalent research experience
- Deep understanding of cardiovascular and metabolic disease epidemiology, particularly Atherosclerotic Cardiovascular Disease (ASCVD)
- Scientific excellence with recognized high-quality publications and clinical/biological expertise in cardiovascular and metabolic diseases (Board certification preferred)
- 5+ years of independent leadership experience and external leadership in consortia and/or health authority initiatives
- Proven success leading multidisciplinary matrix teams across pharma/biotech, academic institutions, or commercial functions with mature biomarker strategy experience
- Ability to own entire portfolio sections and phase packages
- Strong interpersonal skills, presence, and ability to influence senior leadership
- Significant relevant experience in quantitative expertise (biostatistics, bioinformatics, statistical genetics, clinical imaging, machine learning, data science)
- Experience interpreting and publishing omics data studies
- Fluent in English; additional languages (German, French, Italian) useful but not required
This hybrid role is based in Cambridge, MA, with flexibility to work from Basel, Switzerland. The position offers competitive compensation, performance-based bonuses, comprehensive benefits, flexible working options, and 14+ weeks paid parental leave.
