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Dispatch is a biotech company focused on developing novel cancer therapies leveraging viral vectors, universal targets, and novel cytokine biology. The company was founded on pioneering work from leading researchers at University of Pennsylvania, UCSF, Stanford, and Memorial Sloan Kettering.
The Senior Scientist, Analytical Operations will support Dispatch's analytical operations for its portfolio of product candidates, including therapeutic viruses, viral vectors, and autologous and in vivo CAR T cells. Reporting to the Associate Director of Analytical & Product Sciences, this role focuses on creating and managing an effective operational network—both externally and internally—to ensure operational deliverables are met efficiently, effectively, and at high quality.
Key responsibilities include:
- Coordinate execution of external quality control testing, including sample shipments between locations (CDMO to CTL, CDMO to Dispatch)
- Serve as single point of contact between Process Development and Analytical & Product Sciences teams for testing needs
- Manage internal routine testing processes including scheduling, verification, and reporting
- Create and manage systems for seamless data tracking across QC/CTL sites and internal operations
- Develop and manage inventory systems for instrumentation, reagents, cell lines, and reference standards
- Assist with method validation and transfer activities, both internally and with external partners
- Support management and coordination of MSAs and contracts
- Assist with budgeting activities
- Communicate operations status updates and issues to leadership, team members, and stakeholders
- Maintain training and competency on analytical methods (qPCR, ddPCR, cell-based assays, biophysical techniques) and provide lab-testing support as needed
- Participate in seminars, journal clubs, and team meetings; pursue ongoing professional development
This is an individual contributor role with significant operational and coordination responsibilities. The successful candidate will work in a highly cross-functional matrix environment, collaborating with external partners (CDMOs, CTLs) and internal teams.
REQUIREMENTS:
- Ph.D. with at least 5 years of related industry experience, OR Master's Degree with at least 8 years of related industry experience, OR Bachelor's Degree with at least 10 years of related industry experience
- CMC analytical experience within cell and gene therapy and/or large molecule antibody therapy
- Experience with method development, validation, and method transfers in accordance with ICH guidelines
- Lab-based experience developing methods and performing routine testing for at least three of the following analytical platforms: cell-based, Flow Cytometry, Analytical Microscopy, Capillary Electrophoresis, HPLC, AUC, TEM, qPCR, ddPCR, NGS, peptide mapping, residual impurity assays
- Experience scheduling testing for a team (lab-based scheduling of analysts, manufacturing-based scheduling of operators, or equivalent)
- Experience as a lab manager: ordering supplies, organizing reagents, ensuring supply maintenance
- Experience using electronic lab notebook (ELN) systems (Symyx, Benchling, etc.)
- Experience with data analysis software such as GraphPad Prism, JMP, and Microsoft Excel
- Experience with shipping logistics (domestic and international sample shipping)
- Highly organized and proactive in setting up systems and tools for efficient data capture and tracking (LIMS, inventory, data-tracking tools)
- Experience working in highly cross-functional matrix teams
- Strong attention to detail and commitment to accurate, timely documentation
- Experience collaborating with external partners (CDMOs, CTLs) and internal cross-functional teams
- Effective oral and written communication skills
- Familiarity with GMP/GLP laboratory practices or regulated laboratory environment
- Ability to work collaboratively in team-based laboratory environment
- Desire to learn, gain and grow new skills, be adaptable, and apply knowledge in fast-paced dynamic environment
PREFERRED EXPERIENCE:
- Technical understanding of analytical control strategy (release and characterization testing)
- Experience authoring regulatory documents and source reports (IND, BLA, etc.)
- Experience as a Lead or Coordinator on matrix teams
- Experience with project management software/tools (Smartsheet, Microsoft Project)
- Familiarity with data trending
- Familiarity with processes for review and execution of legal contracts and agreements (MSAs, CDAs)
- Familiarity with operational budget development, management, and tracking
