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Salary: USD 109,200 - 140,000 / annual
Altos Labs is seeking a Senior Research Associate to join the Discovery Science team in the San Francisco Bay Area. The company's mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and age-related disabilities.
In this role, you will be a key contributor to developing and executing discovery platforms that support target identification, mechanistic studies, and therapeutic validation. You will work at the interface of cell engineering, perturbation screens, and translational model systems, generating high-quality data in a fast-paced, collaborative environment.
Key responsibilities include:
- Independently maintain, expand, characterize, and troubleshoot mammalian cell culture systems, including immortalized and primary cell models
- Design and execute molecular biology workflows including cloning, plasmid construction, nucleic acid preparation, and mRNA design/synthesis
- Produce, optimize, and deploy viral delivery systems (lentiviral, AAV, and non-viral LNP platforms) for gene perturbation and cellular engineering
- Perform CRISPR-based genome editing, pooled or arrayed perturbation workflows, and validation experiments
- Develop, optimize, and execute robust cell-based assays, reporter systems, and phenotypic readouts
- Maintain exemplary documentation in ELN systems and establish scalable SOPs and laboratory best practices
You bring a BS or MS in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or related discipline, with 2+ years of hands-on experience in biotech, pharma, or leading academic laboratories. You have proven strength in mammalian cell culture, complex bench workflows with high reproducibility, and strong molecular biology experience including cloning and nucleic acid-based assays. Experience with viral transduction, gene delivery, and genome editing platforms is required.
Preferred qualifications include experience with primary human cells, stem cell systems, organoids, functional genomics approaches (CRISPR screens, Perturb-seq), single-cell and spatial omics platforms, flow cytometry, imaging, high-content screening, and interest in aging biology or regenerative medicine.
