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Salary: USD 252,000 - 304,500 / annual
Eikon Therapeutics is a biopharmaceutical company leveraging revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. The company's discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), featuring microscopes that enable real-time, molecular-resolution measurements of protein movement in living cells, unlocking previously intractable protein classes as drug targets.
As Senior Director of Translational Medicine, you will drive biomarker research for the innovative clinical pipeline. You will lead cross-functional teams in developing biomarker strategies, selecting and validating biomarker assays, and analyzing and interpreting biomarker data to support clinical program advancement.
Key Responsibilities:
- Lead one or more cross-functional Biomarker Subteams to develop and implement comprehensive biomarker strategies aligned with oncology clinical program goals
- Establish and maintain strong collaborations with research, clinical development, clinical pharmacology, biostatistics, regulatory affairs, data management, clinical operations, and commercial teams
- Provide strategic input into preclinical and clinical development plans, ensuring seamless translation of scientific findings
- Identify and champion novel translational approaches and technologies to enhance drug development
- Lead identification, validation, and implementation of relevant biomarkers (pharmacodynamic, predictive, prognostic, mechanism of action, safety, resistance) to deliver key trial objectives such as patient selection, dose optimization, and therapeutic response monitoring
- Author biomarker sections of clinical protocols and oversee their execution
- Ensure rigorous, fit-for-purpose analytical validation of selected biomarker assays
- Contribute to the scientific community through publications, presentations, and active knowledge-sharing
- Contribute to health authority interactions and submissions, including INDs, NDAs/BLAs, and CDx filings
- Ensure all translational medicine activities are conducted in compliance with GCP, regulatory guidelines, and ethical standards
The role requires onsite presence at least 3 days per week (or more as business needs require) in the Jersey City, NJ office to ensure effective communication, operational excellence, and high-performance execution of clinical trials.
Qualifications:
- PhD and postdoctoral training in oncology, immunology, or a related field with minimum of 10 years of clinical biomarker development experience in a drug development setting
- Experience translating disease biology and preclinical pharmacology into clinical biomarker strategies that impact the clinical development of oncology therapeutics
- Outstanding strategic and critical thinking skills, with a track record of proactive innovation, scientific excellence, and demonstrated ability to analyze and interpret complex biomarker data
- Ability to work as part of a collaborative team and clearly communicate the impact of biomarker plans and outcomes on clinical development, both orally and in writing
- Expertise in selection, analytical validation, and clinical implementation of assays from a range of biomarker technologies
- Experience evaluating the predictive and prognostic value of biomarkers and familiarity with companion diagnostic development
- Experience conducting data analysis in R or Python preferred
- Ability to excel in a dynamic, fast-moving environment by demonstrating independence, proactivity, creativity, and a solution-oriented mindset
