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Director, Compensation, Benefits and HR Systems

Iambic Therapeutics - San Diego, CA, USA - In-office - posted 2026-09-10

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Iambic Therapeutics, a clinical-stage AI-driven life sciences company founded in 2020, is seeking a Director of Compensation, Benefits and HR Systems to join its growing Human Resources team in San Diego. Reporting to the Head of HR, you will lead the design, implementation, and ongoing management of the company's compensation, benefits, and HR technology platforms. Key responsibilities include: - Leading the company's compensation strategy and programs, including salary structures, job leveling, annual compensation reviews, bonus programs, equity guidelines, promotions, and market benchmarking - Managing executive, employee, and international compensation benchmarking - Overseeing employee benefits programs (health insurance, retirement, leave, wellness) and evaluating competitiveness, cost, and employee experience - Leading annual benefits renewal and open enrollment processes; managing relationships with brokers, consultants, and benefit vendors - Owning HRIS strategy and administration, including PEO exit, ensuring systems, workflows, integrations, reporting, and data accuracy and scalability - Establishing and maintaining policies, controls, documentation, and governance across compensation, benefits, and HR systems - Identifying opportunities to automate and streamline HR processes and improve employee and manager experience - Staying current on market trends, regulatory requirements, and emerging practices in compensation, benefits, and HR technology Iambic is a rapidly growing biotech company with a world-class team combining AI experts and experienced drug hunters. The company has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed across multiple target classes. The role offers the opportunity to build HR infrastructure for a high-growth, venture-backed life sciences company in a brand-new state-of-the-art San Diego facility. QUALIFICATIONS: - Bachelor's degree in human resources, business administration, finance, or related field; Certified Compensation Professional (CCP) preferred - 12+ years of progressive HR experience with significant expertise in compensation, benefits, and/or HRIS, including experience leading total rewards programs - Strong knowledge of compensation benchmarking, salary structures, incentive compensation, equity programs, and job architecture; international experience a plus - Experience managing U.S. benefits programs and working with brokers, consultants, and vendors - Demonstrated HRIS expertise, including system implementation, optimization, reporting, and data governance - Strong analytical skills with ability to translate complex compensation and workforce data into actionable recommendations - Experience partnering with senior executives, Finance, Legal, and HR leadership - Strong project management skills and ability to manage multiple priorities in a fast-paced environment - Experience with successful transition off a PEO, standing up in-house payroll, benefits administration, and HR systems preferred - Experience in a high-growth, biotechnology, technology, or public-company environment preferred

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