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Mirum Pharmaceuticals, a biopharmaceutical company focused on rare disease treatments, seeks a Vice President of Program Leadership to drive global strategy and maximize long-term value of late-stage and commercial-stage products. This is a "Program CEO" role that operates at the intersection of commercial, clinical, regulatory, and operational strategy.
You will lead a cross-functional team spanning U.S. and International Commercial, Development, Regulatory, Medical Affairs, CMC/Technical Operations, Market Access, Finance, and Legal. Your initial portfolio includes LIVMARLI, ATEBRIOZ, CHOLBAM, and CTEXLI.
Key responsibilities include:
- Define and execute integrated global lifecycle strategy for assigned products, establishing long-term vision and value-maximization plans
- Identify and prioritize opportunities across geographies, indications, patient segments, formulations, evidence generation, and regulatory pathways
- Continuously reassess product strategy based on clinical data, competitive developments, market dynamics, regulatory changes, and IP considerations
- Lead cross-functional Program Team decision-making, ensuring trade-offs and resource constraints are identified and resolved
- Evaluate geographic expansion opportunities and commercialization models (direct entry, distributors, partnerships, licensing)
- Lead evaluation of new indications, expanded patient populations, label enhancements, and combination strategies
- Develop and communicate business cases, investment recommendations, and strategic scenarios to executive leadership
- Represent the program externally with thought leaders, prospective partners, and stakeholders
- Manage Program Team budget as part of annual long-range planning
Success requires leading through influence across senior stakeholders, balancing commercial opportunity with scientific/regulatory/operational/financial considerations, prioritizing investments based on patient impact and value creation, translating complex information into clear recommendations, and maintaining both global perspective and near-term execution focus.
QUALIFICATIONS:
- 15+ years biopharmaceutical industry experience, with significant background in commercial strategy, marketing, new product planning, global commercialization, or related leadership roles; rare disease and/or specialty pharmaceuticals experience preferred
- Demonstrated success leading global product or lifecycle strategy for marketed and/or late-stage products, with responsibility for maximizing value across indications, geographies, patient populations, and lifecycle stages
- Strong commercial foundation: product strategy, positioning, forecasting, market development, launch planning, competitive strategy, long-range planning
- Global mindset with ability to incorporate U.S. and international market needs into strategy
- Significant experience leading senior cross-functional teams spanning Commercial, Development, Medical Affairs, Regulatory, Market Access, CMC/Technical Operations, Finance, and other functions; leadership through influence without direct authority
- Ability to operate as enterprise product leader, integrating commercial, clinical, regulatory, medical, technical, and financial perspectives
- Strong strategic and financial acumen: business case development, investment evaluation, P&L understanding, forecasting, resource-allocation recommendations
- Track record of effective decision-making in complex, uncertain situations with competing priorities and cross-functional trade-offs
- Strong understanding of global biopharmaceutical commercialization environment, including clinical evidence, regulatory strategy, market access, pricing/reimbursement, competitive dynamics, and commercial execution
- Demonstrated ability to influence and align senior executives, constructively challenge assumptions, resolve differences, and drive execution
- Excellent executive communication skills; ability to synthesize complex information for executive leadership and governance bodies
- Strong orientation toward patient impact and value creation; ability to balance near-term performance with long-term product potential
- Bachelor's degree required; MBA or other advanced degree preferred
