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Nautilus Biotechnology is developing a single-molecule protein analysis platform to democratize access to the proteome and accelerate drug development. We are seeking a Technical Project Manager to lead the delivery of our comprehensive proteomics platform.
In this role, you will manage multiple medium to large-scale projects across the development lifecycle—from early conception through validation, verification, and internal launch. You will work closely with cross-functional teams in R&D, Product Management, and Manufacturing, serving as a critical bridge between technical teams and leadership.
Key responsibilities include:
- Leading and managing multiple simultaneous projects involving new assays, consumables, software, and hardware components
- Defining project scope, objectives, and quarterly goals aligned with company strategy
- Developing comprehensive project plans, milestones, and deliverables using standard PM tools and dashboards
- Creating and managing detailed schedules in collaboration with technical leads
- Translating technical risks and experimental outlines into actionable plans with measurable metrics
- Identifying and mitigating project risks to ensure on-time milestone delivery
- Facilitating prioritization and tradeoff decisions between schedule, scope, and cost
- Communicating project status effectively to senior management and stakeholders
- Identifying technical resource gaps and working with functional managers on resourcing
- Utilizing tools such as Smartsheet, Jira, and Excel to establish project management processes
- Leading cross-functional meetings and coordinating department-wide communications
You will work independently with minimal supervision, developing strategies and detailed plans while engaging diverse team members to drive toward a launch-ready product. This role requires excellent attention to detail, comfort with technical depth, and the ability to align organizational goals across functions.
Requirements:
- Minimum 8 years of relevant project management experience with focus on product development in biotechnology or life sciences
- Extensive knowledge of the product development process (PDP) and active experience implementing and contributing to it
- Technical expertise in cross-functional projects integrating life sciences, software, hardware, assays, and consumables
- Experience at an early-stage startup
- Bachelor's degree in engineering or science field (Master's or PhD preferred)
- PMP Certification, SAFe, or equivalent Agile Certification required
- Working knowledge of design control, quality systems, and change control as applied to product development and release
- Onsite work required 5 days per week in San Carlos, CA; 5-10% travel may be required
Nice to have:
- Experience taking a product from concept to successful commercial launch, particularly a platform product
- Experience owning or co-owning a commercial launch including manufacturing scale-up and service readiness
- Experience working with Commercial, Marketing, Operations, and Service functions
