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Senior Scientist, Upstream Viral Process Development

Dispatch - Philadelphia, PA, United States - In-office - posted 2026-07-28

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Dispatch is a biotech company focused on developing novel cancer therapies leveraging viral vectors, universal targets, and novel cytokine biology. The company was founded on pioneering work from leading researchers at UPenn, UCSF, Stanford, and Memorial Sloan Kettering, with the mission to create universal treatments across solid tumors. Reporting to the Director of Upstream Process Development, the Senior Scientist will drive upstream viral process development to advance the company's pipeline of T cell and viral vector-based products toward clinical deployment. This is a hands-on technical role combining experimental execution with process development leadership. Key responsibilities include: establishing and organizing the company's viral vector process development capabilities; developing bench-scale suspension culture processes for viral vector generation in shake flasks and bioreactors through systematic experimentation and process characterization; executing process transfer activities between research, operations, and external manufacturing partners; performing day-to-day lab operations including equipment maintenance, materials ordering, and buffer preparation; authoring and reviewing technical documentation (batch records, SOPs, development reports, regulatory sections); representing the company at external meetings with regulatory bodies and professional associations; and serving as a process development subject matter expert for internal teams and external partners including CDMOs and suppliers. Required qualifications: Bachelor's degree in Chemical Engineering, Bioengineering, Biotechnology, or related field with 10+ years relevant experience (or Master's with 8+ years, or PhD with 5+ years); hands-on viral vector upstream processing experience with strong aseptic technique and bioreactor expertise; experience implementing processes in clinical/commercial manufacturing of cell and gene therapy or biopharma products; demonstrated ability to apply cell biology, chemical engineering, or bioengineering knowledge to process development, scale-up, and troubleshooting; strong scientific reasoning and problem-solving skills with applied mathematics and statistics; proven collaboration with internal and external partners; ability to mentor junior colleagues informally; working knowledge of GMP guidelines; proficiency in Microsoft Office and data analysis software (JMP, GraphPad); and excellent communication skills.

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