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Prellis Biologics is seeking a Senior Scientist to lead analytical characterization of therapeutic antibodies and complex biologics. The role focuses on evaluating monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, and related therapeutics to support candidate selection and preclinical development.
Key responsibilities include performing comprehensive analytical characterization using biophysical techniques (Tm, Tagg/Uncle, particle size analysis, AC-SINS, HIC, cIEF, analytical SEC, BVP assays), generating and interpreting analytical data to support lead candidate selection and formulation development, designing and optimizing analytical methods, preparing technical reports, and collaborating with cross-functional teams in Antibody Discovery, Protein Engineering, and CMC.
Required qualifications: Ph.D. or M.S. in Biochemistry, Chemistry, Molecular Biology, Pharmaceutical Sciences, or related discipline; minimum 3 years of industry experience in analytical characterization of therapeutic antibodies or biologics; strong hands-on expertise with protein characterization techniques; demonstrated ability to independently design experiments, analyze data, and communicate findings effectively; excellent organizational and interpersonal skills.
Preferred qualifications include experience with antibody developability and stability profiling, LC-MS-based characterization (intact mass analysis, subunit analysis, peptide mapping, PTM analysis), bioanalysis of serum/plasma samples for PK/PD studies, analytical characterization of antibody-peptide drug conjugates, and knowledge of regulatory expectations for biologics development.
Prellis Biologics is a pre-IPO biotech company in Berkeley integrating human biology with machine learning to develop next-generation antibody therapeutics. The company has raised funding from top-tier investors including Khosla Ventures and SOSV, with pipeline programs spanning obesity, inflammation, immunology, and oncology. The company offers competitive benefits, flexible work arrangements (remote and hybrid options where possible), stock-based incentives, comprehensive health coverage, and career development opportunities.
