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Senior Automation Engineer (I, II, III)

Cellares - South San Francisco, CA, United States - In-office - posted 2026-10-06

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Cellares is an Integrated Development and Manufacturing Organization (IDMO) pioneering Industry 4.0 approaches to mass manufacturing cell therapies. The company develops and operates integrated technologies for cell therapy manufacturing, with the Cell Shuttle platform delivering end-to-end automation for manufacturing processes. Cellares operates Smart Factories globally and is backed by world-class investors with over $355 million in financing. In this Senior Automation Engineer role, you will design and develop automated liquid handling protocols to platform new assays onto the Cell Q system. You will partner closely with Analytical Development to translate manually developed assays into automation-compatible methods, and write and maintain Biosero Green Button Go (GBG) code to implement and integrate automation solutions. Key responsibilities include designing and executing validation experiments to optimize assay and workflow parameters, conducting testing of newly developed automated methods to confirm functionality and performance ahead of formal validation, and troubleshooting and iterating on liquid handler methods and GBG scripts throughout development. You will collaborate with QC, Manufacturing, IT, and Quality to support the transition of developed assays into validated production use, document method development and coding logic to support downstream validation and transfer, and monitor and refine automated workflows based on feedback to improve reliability and performance. This role offers the opportunity to work on cutting-edge cell therapy manufacturing automation at a well-funded, rapidly scaling company. You will have direct impact on enabling life-saving therapies to reach patients globally while working with sophisticated laboratory automation systems and cross-functional teams. REQUIREMENTS: - Bachelor's degree or higher in Engineering, Computer Science, Biotechnology, or related field - 2+ years of experience developing and programming liquid handling automation methods (Tecan Fluent experience preferred) - Hands-on experience coding in Biosero's Green Button Go (GBG) software or equivalent scheduling software - Proficiency in programming languages such as Python or C# - Experience working cross-functionally to platform manual assays onto automated systems - Familiarity with flow cytometry, genomic, and cell-based assays - Experience with laboratory analytical instruments and automated systems - Familiarity with GMP documentation and change control practices, or ability to quickly learn regulated documentation requirements - Strong technical writing skills and experience authoring SOPs, documentation, and training materials - Excellent problem-solving skills and ability to troubleshoot technical issues during method development - Strong communication skills for cross-functional collaboration - Attention to detail and ability to manage multiple development efforts simultaneously - Creative, self-motivated mindset with eagerness to take on diverse tasks and grow with evolving technology - Self-awareness, integrity, authenticity, and growth mindset

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