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Salary: USD 174,068 - 206,706 / annual
BillionToOne is a publicly traded molecular diagnostics company (Nasdaq-listed as of 2025) transforming prenatal and cancer diagnostics through breakthrough cell-free DNA technology. The company has grown from $0 to $400M+ annualized revenue in six years and is now navigating its first full year of SOX 404(b) compliance as a newly public company.
The Senior Accounting Manager will oversee accounting operations and lead a team of GL and AP accountants. This is a hands-on management role reporting to the Director of Accounting, with direct accountability for the month-end and quarter-end close process, general ledger integrity, SOX 404(b) control ownership, and monthly management reporting.
Key responsibilities include:
- Managing the month-end and quarter-end close using FloQast, including journal entry controls, reconciliation sign-offs, and continuous timeline compression while maintaining audit readiness
- Owning general ledger accuracy and integrity in NetSuite, including review of recurring and non-standard journal entries, balance sheet reconciliations, and root-cause resolution of posting issues
- Serving as a named control owner within the SOX 404(b) framework, maintaining control narratives, ensuring IPE (information produced by the entity) completeness and accuracy, and remediating deficiencies
- Acting as the day-to-day point of contact for Big 4 external auditors and consulting advisors, managing PBC requests, walkthroughs, sample pulls, and fieldwork support
- Developing and owning the monthly management reporting package: month-over-month flux analysis by functional area (COGS, R&D, S&M, G&A), cost-per-test analytics for prenatal and oncology products, and executive summaries for the CFO and leadership
- Leading, mentoring, and developing a team of GL and AP accountants across general ledger, fixed assets, accounts payable, and payroll functions
- Operationalizing technical accounting conclusions in areas including ASC 842 lease accounting, ASC 730 R&D cost treatment, and self-funded health plan IBNR reserves
- Driving process improvements to the close and accounting operations for increased speed, efficiency, and operational compliance
- Providing senior oversight of vendor master and disbursement controls, partnering with Supply Chain on procurement governance
The ideal candidate brings experience in a fast-paced, post-IPO environment and demonstrates the ability to drive operational and process improvements at scale.
Qualifications:
- 8-10+ years of progressive accounting experience, including 3+ years managing the close and leading direct reports; post-IPO experience strongly preferred
- Experience in life sciences, diagnostics, or another high-growth regulated industry is a plus
- CPA required with deep US GAAP fluency; Big 4 or national audit firm experience is a plus
- Hands-on SOX 404(b) experience as a control owner, including familiarity with control narratives in functional areas outside accounting & reporting, IPE requirements, and deficiency remediation
- Strong NetSuite experience required, with the ability to query the system directly (saved searches, ideally SuiteQL); FloQast, Expensify, and Workiva experience are pluses
- Advanced Excel and analytical abilities
- Excellent communication and interpersonal skills with cross-departmental collaboration ability
- Bachelor's degree in Accounting, Finance, or a related field
