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Nautilus Biotechnology is developing a single-molecule protein analysis platform to democratize access to the proteome and accelerate drug development. We are seeking a Scientist, Reagent Quality Control to lead the development, optimization, and execution of quality control methods for incoming inspection and in-house reagent production.
In this role, you will own the development and execution of analytical methods including FPLC, HPLC, gel electrophoresis, plate-based assays, and functional sequencing assays to support reagent QC. You will lead lot release, stability testing, and qualification of critical reagents. You will develop and define QC release criteria, specifications, and acceptance limits for reagents in partnership with R&D and Operations teams.
Key responsibilities include leading nonconformance (NC) and out-of-specification (OOS) investigations with structured root-cause analysis, driving corrective and preventive actions (CAPA) to closure, and supporting deviation handling and change control in line with the quality system. You will design and develop new analytical methods, optimize existing QC methods, and mentor junior team members. You will ensure data quality and integrity by establishing best practices and maintaining high standards of organization and detail.
Additional responsibilities include maintaining and organizing work areas (hoods, benches, chemical storage, waste disposal), supporting calibration and maintenance of laboratory instruments, and authoring Standard Operating Procedures, Test Methods, Development Reports, and other quality documentation. You will work independently to troubleshoot failed assays or equipment malfunctions and design experiments to resolve them. This position reports to the Director of Operations and is based in San Carlos, CA.
The ideal candidate will thrive in a cross-functional, fast-paced environment, take ownership of projects, and collaborate effectively with colleagues across disciplines.
REQUIREMENTS:
- PhD in Chemistry, Biochemistry, or related field with 2+ years of relevant industry experience; OR MS with 4+ years of relevant industry experience
- Hands-on experience with HPLC and/or FPLC (AKTA), gel electrophoresis, BLI, and plate-based assays
- Hands-on experience developing QC release criteria, specifications, and acceptance limits, and executing method qualification/validation
- Working knowledge of quality-system processes: nonconformance (NC), CAPA, root-cause analysis, OOS investigations, and change control
- Ability to work independently, lead projects, and collaborate as part of a team
- Desire to work in a highly cross-functional, fast-paced environment
- Willingness to learn and grow within a transformative company
