SlipstreamJobs tracks this role from the company's public career site. Apply directly on the employer's site.
Salary: USD 120,000 - 140,000 / annual
Alamar Biosciences is seeking a Scientist I to join the Content Development team. The company develops innovative approaches to measure critical protein biomarkers from liquid samples using highly multiplexed assays, enabling early disease detection.
In this role, you will support the development, optimization, characterization, and execution of NULISA-based immunoassays and multiplex proteomic panels across diverse disease areas, from early feasibility through customer sample testing. You will work closely with cross-functional partners including R&D, Manufacturing, Bioinformatics, and related teams to ensure robust assay performance and high-quality deliverables.
Key responsibilities include:
- Design, develop, and optimize multiplex proteomic panels, including Alamar's NULISAseq panels and custom panels for external collaborators across various disease areas to support biomarker discovery, validation, and translational research.
- Manage reagent logistics for panels with up to thousands of components (antibodies, conjugates, recombinant antigens, calibrators, controls), including inventory, lot tracking, aliquoting, storage, and stability coordination with Manufacturing and R&D.
- Characterize assay performance for each target, including calibration curves, LLOQ, precision, dilution linearity, spike recovery, and parallelism; evaluate reagent lot-to-lot and instrument-to-instrument consistency.
- Run sample testing studies, including sample receipt and tracking, plate mapping, and reconciliation of sample manifests, run records, and QC reports.
- Analyze and interpret assay data, including data processing, normalization, QC, and statistical evaluation of multi-plate datasets; work with Bioinformatics to summarize results and present findings to internal teams and external collaborators.
- Troubleshoot technical challenges via root-cause analysis across reagent, instrument, sample, and operator factors, and implement corrective strategies.
- Develop and maintain critical documentation, including SOPs, reagent preparation records, and assay transfer documents, and provide input to PRDs to support product development and regulatory compliance.
- Collaborate cross-functionally to advance projects and share technical insights with the team.
The ideal candidate brings strong hands-on immunoassay execution skills, solid foundation in data analysis, and operational discipline for managing many reagents and samples simultaneously while maintaining complex experiment organization and traceability.
REQUIREMENTS:
- Ph.D. in Biochemistry, Molecular Biology, or related discipline; M.S. with 2–5 years of experience will also be considered.
- Hands-on experience with immunoassays or multiplex assay platforms (e.g., Luminex, MSD, Olink, Ella, SomaLogic, etc.).
- Demonstrated experience running multiplex or high-throughput studies involving large numbers of reagents and samples, with strong organizational skills and meticulous record keeping (e.g., reagent inventories, lot tracking, ELN).
- Working knowledge of assay development and validation parameters (e.g., LLOQ, precision, linearity, spike recovery, parallelism).
- Proficiency in Excel and/or R or Python for processing and QC of multi-plate datasets.
- Strong problem-solving and analytical skills with attention to detail in experimental execution.
- Ability to manage multiple projects and timelines in parallel, work collaboratively, and adapt in a fast-paced environment.
- Strong communication skills, including data presentation and technical documentation.
- Plus: Experience with antibody conjugation, recombinant protein handling, or lab automation (e.g., liquid handlers).
- Plus: Familiarity with molecular biology methods (e.g., qPCR, ddPCR, or NGS).
- Plus: Knowledge of biomarker research or clinical sample testing.
