SlipstreamJobs tracks this role from the company's public career site. Apply directly on the employer's site.
Salary: USD 110,000 - 140,000 / annual
Parabilis Medicines is a clinical-stage biopharmaceutical company pioneering a new class of alpha-helical peptides called Helicons™ to modulate intracellular proteins previously considered undruggable. The company's lead program, zolucatetide, is the first direct inhibitor of the β-catenin:TCF interaction and is being evaluated clinically across multiple Wnt/β-catenin-driven diseases including desmoid tumors and familial adenomatous polyposis.
You will join the Hit Discovery team as a Scientist reporting to the Director of De Novo Discovery. This role focuses on advancing the Helicon Discovery Platform through development and application of mRNA display and phage display technologies. You will design and construct diverse mRNA display libraries using molecular biology techniques including PCR, cloning, in vitro transcription/translation, and chemical modification strategies. A key responsibility is expanding chemical diversity by incorporating noncanonical amino acids via reprogrammed or orthogonal translation systems.
You will design and execute high-throughput screening campaigns against challenging protein targets, analyze next-generation sequencing data to identify enriched peptide motifs and assess sequence-activity relationships, and evaluate new technologies and process improvements to enhance platform performance and scalability. Cross-functional collaboration with data science, biochemistry, and medicinal chemistry teams is essential. You will stay current with relevant literature and emerging screening technologies.
This is an ideal opportunity for a recent PhD graduate or early-career scientist to work in a fast-paced, highly collaborative environment focused on building next-generation discovery capabilities and discovering transformative therapeutics.
**Requirements:**
- PhD in Molecular Biology, Biochemistry, Chemical Biology, Bioengineering, or related field, with 0–3 years of postdoctoral and/or industry experience
- Experience with reprogrammed translation systems and genetic-code expansion for site-specific incorporation of noncanonical amino acids into high-diversity peptide libraries (preferred)
- Direct hands-on experience with mRNA display, phage display, or closely related cell-free display technology (desired)
- Strong foundation in chemical and molecular biology techniques, including orthogonal translation systems, cell-free protein synthesis, cloning, and DNA library construction
- Strong biochemistry background and familiarity with next-generation sequencing workflows and data analysis (a plus)
- Demonstrated ability to design and execute experiments independently, troubleshoot effectively, and interpret complex datasets
- Excellent organizational skills, attention to detail, and ability to manage multiple priorities in a fast-paced environment
- Strong written and verbal communication skills with ability to clearly present scientific data
- Collaborative mindset with high degree of initiative, curiosity, and enthusiasm for platform innovation and drug discovery
