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Iambic Therapeutics, a clinical-stage biotech company founded in 2020, is seeking a Research Scientist to join its Discovery Chemistry team in San Diego. The company develops novel medicines using an AI-driven discovery and development platform, with a track record of advancing drug candidates to human clinical trials with unprecedented speed across multiple target classes.
In this role, you will design and execute parallel synthetic methods to generate large, high-quality compound libraries for drug discovery. You will identify, develop, and optimize novel synthetic methodologies with a focus on automation compatibility and high-throughput experimentation (HTE) scalability. A key responsibility is translating newly developed synthetic routes from traditional bench-scale chemistry into robust, automated, high-throughput processes. You will oversee the operation, maintenance, and continuous advancement of the chemistry toolkit and automated synthesis equipment.
You will analyze research outcomes and library compound data, communicating results clearly to cross-functional project teams spanning chemistry, biology, compound management, AI/ML, and software. You'll ensure all laboratory work adheres to established safety protocols and best practices for electronic lab notebook (ELN) data recording. As a core member of an interdisciplinary scientific team, you will proactively identify bottlenecks in automated processes, troubleshoot issues, and develop solutions to ensure business continuity.
The ideal candidate will leverage Iambic's HTE platform to accelerate and strengthen discovery programs, working in a fast-paced, highly collaborative environment where priorities may shift rapidly based on biological data.
Requirements:
- Ph.D. in Organic Chemistry with 0–5 years of industry experience, OR M.S. in Organic Chemistry with a minimum of 8 years of industry experience.
- Strong command of modern organic synthetic methods.
- Direct hands-on experience with High Throughput Chemistry and/or Parallel Synthesis.
- Experience with laboratory automation, liquid handling robotics, and automated analytical and purification systems.
- Ability to thrive in a fast-paced, highly collaborative, dynamic research environment.
- Excellent written and verbal communication skills; ability to articulate complex scientific concepts, technical challenges, and results clearly to diverse audiences.
- Proven ability to work in a high-volume environment where synthetic targets may shift rapidly based on biological data.
Strongly Preferred:
- Experience with Direct-to-Biology (D2B) strategies for drug discovery.
- Familiarity with medicinal chemistry principles.
- Prior experience mentoring interns or junior colleagues.
