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Isomorphic Labs is an AI-driven drug discovery company applying frontier machine learning to accelerate scientific breakthroughs and develop life-changing medicines. The company was launched in 2021 to advance human health by building on the Nobel-winning AlphaFold system, combining drug discovery expertise with machine learning innovation.
The Preclinical Development team accelerates delivery of high-quality drug candidates by developing AI-first solutions for safety, druggability, and developability. As Research Leader (Toxicology), you will develop safety assessment strategies for drug discovery and development projects from inception through regulatory submission, working closely with drug design platforms for small molecules and biologics.
Key responsibilities include:
**Discovery and Development Support:**
- Design and implement safety assessment strategies with an AI-first approach for small molecule and biologics projects
- Design screening cascades and mechanistic experiments to support project progression in a data-driven manner
- Develop structure-activity relationship (SAR) understanding of toxicology liabilities to optimize chemical and biological matter
- Define regulatory safety assessment packages for successful regulatory agency acceptance
- Author toxicology sections of regulatory documents
**Predictive Toxicology Strategy:**
- Partner with Machine Learning colleagues to build predictive toxicology aspects of the drug design platform
- Identify, generate, and analyze data to develop and improve predictive toxicology models
- Identify state-of-the-art technologies and methods that could bring transformational benefits to the platform
**CRO Interactions:**
- Maintain and develop close relationships with the CRO network to ensure high-quality, timely data generation
- Leverage external collaborators' scientific expertise to enhance team impact
- Oversee delivery of data generation campaigns designed to support AI-based toxicology model development
**People:**
- Mentor junior team members
- Champion a culture of inclusion and continuous professional development
The role requires hybrid work with 3 days per week in the Cambridge office (typically Tuesday, Wednesday, and one additional day).
**Requirements:**
Essential:
- Ph.D. in Toxicology, Pharmacology, Biology, or DVM/MD with relevant experience
- Board Certification in toxicology
- Extensive professional experience in senior toxicology roles across different therapy areas in biotech or pharma
- Demonstrated experience filing successful INDs/CTAs for both small molecules and biologics
- Deep understanding of Global Regulatory Guidelines regarding safety assessment
- Experience partnering closely with Discovery and Clinical teams
- Excellent written and verbal communication, interpersonal and influencing skills
- Ability to work effectively in cross-functional, collaborative team environments
- Track record of creative problem-solving with strong growth mindset, adaptability, and willingness to challenge conventional thinking
Nice to have:
- Experience with peptides and other new drug modalities
- Understanding of machine learning techniques
- Familiarity with Python and KNIME
