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Salary: USD 127,991 - 149,323 / annual
BillionToOne is a publicly traded molecular diagnostics company (Nasdaq) focused on transforming prenatal and cancer diagnostics through proprietary QCT technology. The company has grown from $0 to $400M+ annualized revenue in 6 years and is backed by leading investors including Hummingbird, Adams Street Partners, and Neuberger Berman.
The Reporting Clinical Laboratory Scientist (RCLS) is a senior individual contributor role responsible for high-complexity clinical laboratory data analysis, interpretation of molecular diagnostic and sequencing results, and ensuring accurate, reliable, and timely reporting of patient results. This role combines deep technical execution with mentorship and process improvement leadership.
Key Responsibilities (70% Analysis and Reporting):
- Execute validated bioinformatics pipelines to process and analyze molecular diagnostic data from patient samples
- Independently review, interpret, and troubleshoot clinical genomic data, including next-generation sequencing (NGS) results and quality control metrics
- Identify, investigate, and resolve analytical discrepancies and data quality issues in collaboration with Bioinformatics teams
- Independently review, verify, and release clinical laboratory reports in accordance with CLIA, CAP, and California regulatory requirements
- Manage daily sample analysis priorities and proactively communicate technical issues affecting reporting accuracy or turnaround times
- Collaborate with RCLSs, Bioinformatics, Genetic Counselors, and Laboratory Directors on complex findings and reporting discrepancies
Key Responsibilities (30% Technical Leadership, Quality Assurance, and Operations):
- Demonstrate technical leadership by independently investigating complex analytical issues and providing guidance to colleagues
- Support training and mentoring of Reporting CLS personnel and other clinical laboratory staff
- Perform quality control and quality assurance activities; identify, document, and investigate quality-related issues
- Collaborate with Quality Management on root cause investigations and corrective/preventive actions
- Identify and recommend opportunities to optimize analytical workflows and improve reporting accuracy
- Support development, validation, and implementation of new laboratory tests and analytical methodologies
- Serve as technical resource for cross-functional teams addressing clinical reporting questions and troubleshooting analytical issues
The role is hybrid (60% on-site, 40% remote), requiring approximately three days per week on-site at Union City and/or Menlo Park offices and two days per week remote. The position requires exceptional attention to detail, strong analytical and problem-solving skills, excellent written and verbal communication, and the ability to manage multiple priorities in a fast-paced clinical laboratory environment.
Qualifications:
- Must possess an active and valid California CLS (Clinical Laboratory Scientist) or CGMBS (Clinical Genetic Molecular Biologist Scientist) license
- Bachelor's degree or higher in Biomedical Laboratory Sciences, Clinical Laboratory Science, Molecular Biology, Genetics, or related scientific discipline
- At least one year of clinical laboratory experience in a high-complexity, high-volume molecular diagnostic clinical laboratory environment
- Working knowledge of molecular biology principles, clinical laboratory testing methodologies, and applicable local, state, and federal laboratory regulations
- Demonstrated experience with sequencing data analysis, including evaluation and interpretation of NGS results and associated analytical quality control metrics
- Demonstrated ability to independently analyze complex laboratory data, investigate discrepancies, and troubleshoot issues affecting test performance or reporting accuracy
- Familiarity with bioinformatics analysis outputs and their application to clinical molecular diagnostic reporting
- Strong computer skills and ability to use laboratory data management systems and analytical software; proficiency with Atlassian Suite, Google Workspace, and Microsoft Office Suite
- Strong analytical judgment, attention to detail, organizational and problem-solving skills
- Ability to independently manage reporting responsibilities, prioritize competing demands, and adapt to changing operational needs
- Demonstrated initiative and accountability in investigating technical issues and exercising appropriate judgment regarding consultation and escalation
- Excellent written and verbal communication skills with ability to provide technical guidance and collaborate across multidisciplinary teams
- Receptiveness to feedback and commitment to continuous learning and process improvement
Preferred Qualifications:
- Experience with clinical molecular diagnostic data analysis and reporting in high-complexity laboratory environments, including Sanger sequencing, trinucleotide repeat analysis, MLPA, or other molecular diagnostic methodologies
- Experience investigating complex analytical discrepancies and unusual sequencing findings
- Familiarity with bioinformatics workflows, laboratory information management systems (LIMS), command-line interfaces, and molecular diagnostic data analysis tools
- Experience providing technical guidance, mentoring, or training to clinical laboratory personnel
- Experience supporting laboratory workflow optimization, assay validation, technology transfer, or process improvement initiatives in collaboration with Bioinformatics or R&D teams
