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Salary: USD 108,500 - 201,500 / annual
DTX Pharma, a Novartis Company, is seeking a Principal Scientist I or II in Oligonucleotide Chemistry & Innovation to advance the next generation of RNA therapeutics. You will play a critical role in building and advancing Novartis' xRNA therapeutic platform, bringing scientific creativity and technical expertise to drug discovery.
Key Responsibilities:
- Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides and conjugates
- Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies
- Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates
- Drive cross-functional collaboration to advance oligonucleotide therapeutic programs from discovery through preclinical stages
- Mentor scientists and enhance laboratory workflows to improve efficiency, quality, and innovation
- Establish and maintain standard operating procedures supporting reproducible oligonucleotide manufacturing processes
- Operate, troubleshoot, and maintain critical analytical and synthesis instrumentation, including HPLC and LC-MS
Required Qualifications:
- PhD in Chemistry or related scientific discipline
- At least 5 years of experience synthesizing therapeutic oligonucleotides in industry or research settings
- Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification, and characterization
- Proven experience developing and optimizing novel oligonucleotide chemistries and conjugates
- Strong knowledge of phosphoramidite chemistry and modern synthetic chemistry techniques
- Hands-on experience operating automated oligonucleotide synthesizers and analytical instrumentation
- Demonstrated understanding of RNA therapeutics, including siRNA and antisense oligonucleotides
- Excellent collaboration and communication skills with ability to work across multidisciplinary teams
This role offers the opportunity to make meaningful scientific impact while mentoring others and contributing to breakthrough therapies that could transform patient outcomes. Relocation support is available. The position is based in Cambridge, MA with hybrid working options where possible.
