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Precision for Medicine is seeking an exceptional Principal Database Programmer to join their European team in a fully remote, permanent position. This role is responsible for managing all programming aspects of clinical databases throughout the study lifecycle—from development and testing through implementation, maintenance, and post-database lock support. The position requires close collaboration with Data Management, Project Management, EDC vendors, clients, and third-party vendors to ensure databases are developed, maintained, and compliant with regulatory guidelines.
Key responsibilities include leading operational study teams and programming team members on assigned studies and programs; providing operational and technical training to end users and junior staff; and delivering planning estimates for project scope, schedules, timelines, forecasting, and resource requirements. The role involves designing and building clinical databases, developing and validating programs to support client projects and third-party applications, providing system administration and advanced technical support, troubleshooting software and database issues, and developing study-specific validation documents. Additional duties include supporting data management from CRF design through post-database close and archival, participating in software vendor selection and EDC demonstrations, developing and maintaining SOPs, onboarding new hires, leading cross-functional initiatives, and communicating with study sponsors, vendors, and project teams regarding data and database issues.
Required qualifications include a minimum of 8 years' experience with a Bachelor's degree or equivalent combination of related experience. Strong expertise in Oncology (with Autoimmune disease experience preferred), proficiency with Rave and Veeva systems, and Object-Oriented Programming (C#, C++, VBS, etc.) are essential. Candidates must demonstrate understanding of CDISC standards (CDASH, SDTM, ADaM), proficiency in multiple CDMS systems with ability to build forms and complex rule development, broad knowledge of drug, device, and biologic development, and strong clinical database management system development experience. Excellent organizational and communication skills, professional English proficiency (written and oral), strong leadership and interpersonal skills, and experience in clinical, scientific, or healthcare disciplines are required.
