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Salary: USD 265,000 - 295,000 / annual
Ascendis Pharma is a global biopharmaceutical company advancing programs in endocrinology rare disease and oncology, leveraging its proprietary TransCon® drug development platform. The Medical Director, Clinical Development will be a key member of the clinical development team, based in Palo Alto and reporting to the Vice President, Clinical Science.
The role encompasses design, monitoring, data analysis, and interpretation of late-phase clinical trials in endocrinology. Key responsibilities include:
• Contributing to formulation and implementation of the Clinical Development Plan
• Leveraging medical expertise and hands-on clinical experience to ensure relevance and rigor of the development program
• Designing clinical trials, providing overall oversight, and supporting site and subject retention
• Serving as Medical Monitor for clinical trials, ensuring study integrity and tracking safety/efficacy data
• Providing leadership to teams of medical monitors and study teams
• Ensuring successful completion of trial-related documents (protocols, investigator brochures, monitoring plans, training materials, clinical study reports, regulatory submissions, SOPs)
• Analyzing, evaluating, interpreting, and reporting clinical data
• Anticipating and solving complex drug development problems
• Contributing to regulatory strategy and clinical document/manuscript/presentation drafting
• Maintaining current knowledge of relevant science, medical information, GCP, and regulatory guidance
• Collaborating cross-functionally with clinical operations, statistics, regulatory affairs, medical affairs, HEOR, commercial, and finance teams
• Cultivating relationships with investigative sites, clinical consultants, and key opinion leaders
• Assisting in portfolio management and commercial activities as needed
• Travel up to 20% domestically and internationally for scientific meetings
Requirements:
• M.D. degree (required)
• Completion of ACGME-accredited residency and fellowship (strongly preferred)
• Physician licensure in at least one state (strongly preferred)
• Board certification with specialty in endocrinology (strongly preferred)
• At least 5 years of industry experience (post-graduate clinical/academic experience may be considered case-by-case; those with less experience may be considered for Associate Medical Director role)
• At least 3 years of experience with clinical trial design and execution
• Strong track record of scientific and clinical inquiry
• Excellent written and oral communication skills
• Ability to learn quickly, follow complex directions under pressure
• Strong organizational and attention-to-detail skills
• Leadership ability both directly and by example
• Collaborative team player with initiative and problem-solving capability
• Sound judgment in handling complex, confidential, and regulated information
