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Level Zero Health is a venture-backed biosensor startup (backed by SOSV and Entrepreneur First, recognized as a top 20 startup at TechCrunch Disrupt 2024) developing next-generation continuous monitoring devices for endocrine biomarkers using aptamer-based sensor technology.
You will lead the development and commercialization of the company's continuous aptamer sensor platform, taking electrochemical sensor systems from bench concept through manufacturing readiness. Key responsibilities include:
- Lead development and optimization of electrochemical continuous sensor systems, progressing from concept to manufacturing-ready products
- Design and execute large-scale analytical verification studies covering multi-parameter performance characterization, stability assessments, and biocompatibility validation
- Oversee in vivo validation studies in human subjects and troubleshoot sensor performance in clinical settings
- Define manufacturing processes, material specifications, and quality control parameters aligned with regulatory frameworks (ISO 13485, GMP)
- Engage directly with regulatory pathways (FDA, EMA) to define performance specifications and shape submission strategy
- Lead cross-functional efforts with electrochemistry, microfabrication, and manufacturing teams to translate designs into scalable production
- Develop technical documentation packages (CMC, analytical performance dossiers) for regulatory submissions and investor communications
- Mentor junior scientists and technicians in sensor characterization and assay validation
Required qualifications: Ph.D. in electrochemistry, materials science, biomedical engineering, or related discipline with focus on electrochemical biosensors. Minimum 4 years of industry experience commercializing continuous monitoring or diagnostic sensor technologies. Essential expertise includes deep experience in electrochemical sensor development (amperometric, potentiometric, or impedance-based platforms), proven track record managing regulatory submissions (FDA 510(k), De Novo, CE marking), large-scale analytical verification study design and execution, in vivo validation study experience, manufacturing readiness and scale-up strategy, QMS-ready environments, biocompatibility and shelf-life requirements, surface chemistry and biointerface optimization, and aptamer-based biorecognition elements.
Nice-to-have skills include experience with microneedle/transdermal ISF technologies, SELEX or aptamer discovery workflows, and MEMS/electrode microfabrication.
Full-time, in-person role based in London. Competitive salary and equity options offered. You'll work directly with the founding team in a mission-driven startup environment focused on revolutionizing personalized health monitoring.
