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Salary: USD 215,000 - 275,000 / annual
Frontier Medicines is seeking a Director of Clinical Supply Chain to build and lead clinical trial supply strategy across a growing clinical portfolio. This is a hands-on, high-visibility role responsible for ensuring investigational product is forecasted, packaged, labeled, and delivered to clinical sites on time and in compliance with GMP/GCP requirements. The role reports to the Head of Technical Operations and CMC and will partner closely with CMC, Clinical Operations, Quality, and Regulatory Affairs.
Key responsibilities include:
- Own end-to-end clinical supply chain strategy for active and upcoming trials
- Develop and maintain clinical drug supply forecasts and demand plans, translating protocol design, enrollment projections, and dosing regimens into packaging, labeling, and distribution plans
- Select and manage clinical packaging, labeling, and distribution vendors, including oversight and performance management of CMOs/CPOs and specialty distribution/depot partners
- Own Interactive Response Technology (IRT/IWRS) requirements, build, and testing in partnership with Clinical Operations, and serve as the clinical supply lead on IRT vendor management
- Manage comparator and ancillary supply sourcing, including global sourcing strategies where applicable
- Oversee cold chain and temperature-controlled logistics, expiry/re-test date management, and label reconciliation across depots and sites
- Partner with CMC/Technical Operations to align clinical supply timelines with drug substance and drug product manufacturing schedules
- Ensure compliance with GMP, GCP, and applicable import/export regulations across all clinical supply activities, including serialization and country-specific labeling requirements
- Support regulatory submissions with clinical supply chain content (e.g., IMPD/IND sections, label text) in partnership with Regulatory Affairs and Quality
- Manage clinical supply budget, purchase orders, and vendor invoicing in partnership with Finance
- Build scalable clinical supply chain processes and systems as Frontier's clinical portfolio and trial complexity grow
Requirements:
- Bachelor's degree in a scientific, supply chain, or related field; advanced degree a plus
- 8+ years of clinical supply chain experience in biotech or pharma, including oncology trial experience (Director level)
- Direct experience with IRT/IWRS systems, clinical packaging and labeling, and global clinical distribution
- Working knowledge of GMP/GCP requirements as they apply to clinical supply
- Experience managing CMO/CPO and distribution/depot vendor relationships
- Strong cross-functional collaboration skills, particularly with CMC/Technical Operations, Clinical Operations, Quality, and Regulatory Affairs
- Comfortable in a fast-paced, dynamic environment; proactive, roll-up-your-sleeves mindset appropriate for a lean, growing organization
- Legally authorized to work in the United States
