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Relation is a TechBio company developing transformational medicines using single-cell multi-omics, functional assays, and machine learning to drive disease understanding and drug discovery. The company operates state-of-the-art wet and dry labs in London and is scaling rapidly with interdisciplinary teams spanning biology, computation, and engineering.
As Director of Clinical Pharmacology, you will lead the clinical pharmacology and pharmacometric capability supporting Relation's product development portfolio. You will serve as the core quantitative and clinical pharmacology lead within cross-functional project teams, working across Translational Safety, in vivo Pharmacology, and Biomarkers to drive end-to-end asset development from target assessment through clinical support. Your scope spans small molecules, large molecules, and novel platforms across multiple disease areas.
Key responsibilities include:
- Building and owning clinical pharmacology capability, setting standards for excellence and championing innovative approaches
- Acting as Clinical Pharmacology lead for multiple concurrent programmes, overseeing clinical pharmacology input into study design from IND-enabling through Phase 1, 2, and 3 trials
- Integrating nonclinical and clinical data to continuously improve predictive accuracy
- Leading modelling and simulation approaches including non-clinical to clinical PK/PD, DDI risk assessment, PBPK, population PK/PD, and QSP to support dose selection and data-driven decisions
- Leading and managing external collaborations and CRO partnerships
- Authoring regulatory documents including Investigator's Brochures, INDs, and NDA/BLA/MAA submissions
- Identifying and incorporating emerging AI-enabled approaches into clinical pharmacology workflows
- Interfacing with cross-functional teams including DMPK, translational safety, toxicology, biology, clinical operations, and regulatory affairs
- Translating quantitative and biology data into actionable insights for project teams and senior stakeholders
- Maintaining rigorous documentation standards
The role is hybrid, based at Relation's facility in central London, and sits within the Drug Discovery team in a matrixed environment supporting multiple disease areas as the portfolio grows.
REQUIREMENTS:
- PhD, PharmD, or MD with specialisation in DMPK, Pharmacometrics, in vivo/Clinical Pharmacology, or related scientific discipline, or equivalent industry experience in a lead Quantitative Clinical Pharmacology position
- Significant pharmaceutical or biotech industry experience in Quantitative Clinical Pharmacology spanning all development stages
- Strong understanding of drug discovery, nonclinical and clinical development with proven track record applying Model-Informed Drug Development (MIDD) principles
- Experience across therapeutic modalities (small molecules, biologics, novel platforms) beneficial
- Strong foundation in in vivo Pharmacology and Clinical Pharmacology principles with demonstrable experience in advanced quantitative modelling (NONMEM, R, Monolix, WinNonlin, GastroPlus, SimCyp)
- Proficiency in data analytics and emerging AI-enabled approaches
- Understanding of regulatory landscape and integration of diverse data for efficient development
- Outstanding communication skills with ability to translate complex quantitative data into strategic messages
- Comfort working in matrixed environments with multiple stakeholders
- Ownership mindset, proactive contribution, and ability to enable others
- Open, direct communication with constructive feedback skills
- Ability to seek diverse perspectives and build strong working relationships
- Resilience and high standards for meaningful outcomes
