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Cartography Biosciences is an oncology-focused biotech company developing antibody-based therapies powered by proprietary AI/ML-driven discovery platforms (ATLAS and SUMMIT). The company combines petabyte-scale single-cell profiling data with machine learning to identify highly specific tumor targets and logic-gated combinations. The lead program, CBI-1214, is a T-cell engager currently in phase 1 clinical trials for colorectal cancer.
The Associate Scientist will join the Pharmacology team to drive in vitro development and characterization of novel T cell engagers across the pipeline. This is a hands-on, lab-focused role centered on high-throughput functional screening and secondary characterization assays.
Key Responsibilities:
- Execute high-throughput in vitro screening assays for T cell engagers, including in vitro cytotoxicity assays
- Perform characterization assays using flow cytometry
- Maintain and expand primary cell culture (PBMCs, primary T cells) and cancer cell line cultures
- Design, execute, and troubleshoot assays independently and collaboratively
- Maintain accurate records in electronic lab notebook (ELN) and contribute to SOP development and assay documentation
- Analyze, visualize, and interpret experimental data using FlowJo, GraphPad Prism, Excel
- Contribute to general lab operations including reagent preparation, equipment maintenance, and inventory management
- Summarize and present experimental results and progress at team meetings
Requirements:
- Bachelor's or Master's degree in Biology or related scientific field
- 3+ years of hands-on laboratory experience in academia or industry
- Proficiency in tissue culture, including primary cell culture (PBMCs, primary T cells) and cancer cell line maintenance
- Experience in T cell biology and in vitro functional assays
- Hands-on experience with flow cytometry
- Strong analytical skills with ability to independently analyze, interpret, and troubleshoot experimental data
- Excellent organizational skills, attention to detail, and accurate record-keeping (ELN)
- Self-motivated, adaptable, and proactive in fast-paced environment
- Demonstrated team player with professional and positive attitude
- Strong written and oral communication skills
- Able to be on-site in person 5 days a week
Preferred:
- Experience working with T cell engagers
- Familiarity with TDCC and on-cell binding assays
- Experience with data analysis software such as FlowJo and GraphPad Prism
