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Salary: USD 280,000 - 355,000 / annual
Dispatch is a clinical-stage biotech company focused on developing universal cancer treatments leveraging novel viral vectors, universal targets, and cytokine biology. Founded on pioneering work from leading academic researchers (Dr. Carl June, Dr. Kole Roybal, Dr. Christopher Garcia, Dr. Andy Minn), the company is entering the clinic with its first-in-human study.
You will establish and lead the Biometrics function from the ground up, reporting to the Chief Medical Officer. This is a builder's role where you will define biostatistics, statistical programming, and clinical data management strategy, standards, processes, and vendor models as the company scales. Initially, you will be a hands-on leader performing much of the work yourself, with the opportunity to build and scale a team as the pipeline grows.
Key responsibilities include:
- Building the biometrics function from scratch: strategy, operating model (in-house vs. outsourced), SOPs, data standards (CDISC SDTM/ADaM), templates, and analysis infrastructure
- Serving as the hands-on lead statistician for the first-in-human study, authoring and reviewing statistical sections of protocols, statistical analysis plans, TLF specifications, and data review plans
- Providing statistical leadership on early-phase design, including dose-escalation/expansion strategies, model-based and Bayesian dose-finding methods, and designs with efficacy/futility boundaries
- Driving timely interpretation of emerging safety and efficacy data (ORR, duration of response, PFS, OS) to inform safety committees and program decisions
- Partnering with Clinical Development on clinical development plans, sample size analyses, and probability-of-success evaluations
- Leading statistical content of regulatory interactions and submissions (IND amendments, annual reports, end-of-phase meetings, BLA readiness)
- Overseeing clinical data management, including EDC build, data quality strategies, database lock, and inspection readiness
- Selecting, contracting, and managing CROs and biometrics vendors
- Collaborating with Translational Science to integrate biomarker and pharmacokinetic data
- Evaluating innovative methods (AI/ML, external controls, real-world data) to strengthen analyses
- Ensuring accuracy of external data communications (abstracts, presentations, publications)
- Scaling the function as the portfolio grows, hiring and developing team members
You will work closely with the VP Regulatory Affairs, VP Clinical Operations, VP Clinical Development, Head of Program and Portfolio Management, and Product Team Leads, as well as colleagues in Translational Science, Research, and Technical Operations.
REQUIREMENTS:
- Ph.D. in Statistics, Biostatistics, or related quantitative field
- At least 15 years of clinical development statistics experience in biopharmaceutical industry with progressive leadership responsibility, including leading a biostatistics/biometrics function or serving as lead statistician across multiple programs
- Substantial hands-on oncology experience, including design and analysis of early-phase oncology studies and familiarity with oncology endpoints and response criteria (RECIST, time-to-event endpoints)
- Demonstrated expertise in innovative early-phase designs (dose-escalation, dose-expansion)
- Direct experience leading statistical contributions to FDA interactions and regulatory submissions (IND, end-of-phase meetings); contribution to at least one BLA/NDA/MAA
- Strong working knowledge of ICH guidelines (E9/E9(R1)), GCP, CDISC standards, and relevant FDA guidance
- Proven track record selecting and overseeing CROs and functional service providers in outsourced operating models
- Hands-on proficiency in SAS and/or R with willingness to personally perform and QC analyses
- Comfort operating as a leader with a small team (initially none) and strong desire to build
- Collaborative nature, geared toward cross-functional teamwork; able to influence peers and leaders without relying on hierarchy
- Excellent organizational, problem-solving, and time management skills with judgment to manage competing priorities
- Positive attitude, dedicated work ethic, and flexible orientation for fast-paced, entrepreneurial environment
- Strong verbal and written communication skills, including ability to translate complex technical concepts for diverse audiences
- Comfortable giving and inviting candid feedback and flagging risks early
PREFERRED EXPERIENCE:
- Experience with cell therapy (CAR T) or gene therapy programs, including cellular kinetics and immune-related safety events (CRS, ICANS)
- Oncology experience, especially solid tumors and gastrointestinal cancers
- Experience supporting expedited regulatory pathways (Breakthrough Therapy, accelerated approval)
- Experience with Bayesian methods, external control arms, or real-world evidence in regulatory context
- Prior experience as first or founding biometrics leader at early-stage biotech
- Experience supporting ex-US clinical studies
- Experience supporting business development diligence, financing, or IPO-related data activities
