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Salary: USD 70,500 - 78,000 / annual
Terray Therapeutics is a venture-backed biotechnology company combining nanotechnology, experimental science, machine learning, and automation to transform small-molecule drug discovery and development. The company's EMMI platform (Experimentation Meets Machine Intelligence) powers iterative cycles of molecular design and wet-lab experimentation.
You will join the Analytical and Purification group as a detail-oriented technician supporting synthetic chemistry programs. Your primary focus (80% of time) will be technical operations: identifying, purifying, and characterizing small-molecule compounds using chromatographic and mass spectrometry techniques. You will operate an open-access/walk-up purification service, delivering high-purity compounds and analytical data to requestors on fast, flexible timelines, and maintaining instrumentation and workflows that keep the discovery pipeline moving.
Core responsibilities include:
- Develop and optimize analytical and preparative methods on LC/SFC-MS platforms using reversed-phase and normal-phase prep-HPLC, mass-directed prep-HPLC, and flash chromatography
- Run high-throughput analysis and characterization of crude reaction mixtures and purified compounds, confirming identity and purity by UPLC/HPLC-UV, LC-MS, and NMR as needed
- Support the walk-up LC-MS and purification service, assessing incoming samples and returning purified material and data with quick turnaround
- Accurately track sample identity, recovery, and yield through analytical and purification workflows
- Perform routine preventive maintenance, calibration, and troubleshooting of analytical and preparative instrumentation and associated software, escalating vendor service as needed
- Maintain accurate, current, well-organized records of all work in accordance with laboratory data integrity and safety standards
- Follow all safe laboratory practices and contribute to a clean, well-run shared instrument environment
The remaining 20% of your time will focus on continuous improvement and ad-hoc R&D projects to improve internal capabilities. Additional opportunities may include assisting in workflow efficiency improvements, throughput optimization, and cross-team projects.
The role is laboratory-based, requiring routine work with solvents and reagents under appropriate engineering controls and PPE. You will stand for extended periods and lift laboratory items (typically up to ~40 lbs). After a 30-day training period on a Monday-Friday 9AM-5PM schedule, you will transition to a permanent 4-day, 10-hour schedule: either Saturday-Wednesday or Wednesday-Saturday, depending on your preference.
**Requirements:**
Required Qualifications:
- B.S. in Chemistry, Analytical Chemistry, Organic Chemistry, Biochemistry, or related discipline
- Hands-on experience with analytical and preparative scale chromatography (HPLC/UPLC and prep-HPLC)
- Working knowledge of chromatographic principles (reverse and normal phase chromatography, mobile/stationary phase selection, related chemical knowledge)
- Very strong attention to detail, sample tracking discipline, and data integrity habits
- Ability to manage high sample throughput and competing priorities in a deadline-driven environment
- Strong written and verbal communication skills; works effectively both independently and as part of a collaborative, cross-functional team
Preferred Qualifications:
- B.S. with 1–3+ years of relevant industry experience, or M.S. with 0+ years of experience
- Ability to operate and troubleshoot chromatography and MS hardware and software (Agilent 1100/1200/1260/1290 series with ChemStation/OpenLab, Waters systems with MassLynx/FractionLynx, ThermoFisher XCalibur/Chromeleon, or comparable)
- Experience with mass spectrometry/gas phase chemistry and hyphenated techniques (LC-MS, GC-MS, MS-MS) for compound identification
- Knowledge of small molecule and general synthetic chemistry
- Experience with MS-directed/mass-triggered preparative purification and automated open-access purification platforms
- NMR interpretation for structure confirmation and purity assessment
- Experience supporting medicinal chemistry or small-molecule drug discovery programs in pharma or CRO setting
- Familiarity with instrument automation, electronic lab notebooks, and chromatography data systems
