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Salary: USD 125,000 - 170,000 / annual
Frontier Medicines, a clinical-stage biotech company, is seeking two Senior Clinical Trial Managers to support the execution of oncology clinical trials through clinical development. You will work under the guidance of the Sr. Director of Clinical Operations, serving as a key operational contact for CROs and trial sites.
Key responsibilities include:
- Support day-to-day clinical trial activities including feasibility assessments, site selection, start-up, maintenance, and close-out
- Serve as primary operational point of contact for CROs and trial sites, identifying and escalating issues
- Oversee CRO and vendor setup, liaising to ensure timely study initiation
- Review site-level regulatory documents (ICFs, essential documents) and escalate as needed
- Ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements
- Identify operational challenges and propose mitigation plans in partnership with senior team members
- Review protocols, master template ICFs, case report forms, and clinical study documents
- Monitor study performance metrics, timelines, deliverables, and CRO trip reports for trends and quality issues
- Track study budgets and vendor invoices/change orders, flagging discrepancies
- Maintain study registration and updates on ClinicalTrials.gov and other registries
- Coordinate Clinical Trial Team meetings and drive action item follow-up
- Maintain clinical operations trackers, databases, and document repositories
- Provide regular study updates to internal stakeholders and support enrollment, database lock, and closeout activities
This is a hybrid role based in Boston, MA with an expectation of 2-3 days per week onsite, plus periodic travel to trial sites and CRO/vendor meetings.
Requirements:
- Bachelor's degree in a scientific, healthcare, or related field, or RN certification (required)
- 5-7 years of Clinical Trial Manager, SCTM, or Clinical Project Management experience
- Experience supporting oncology clinical trials strongly preferred
- Vendor and CRO management experience
- Strong working knowledge of ICH-GCP guidelines and clinical trial regulations
- Excellent organizational, problem-solving, and time management skills with strong attention to detail
- Strong written and verbal communication skills with collaborative, team-oriented approach
- Comfortable in fast-paced, dynamic environment with proactive, roll-up-your-sleeves mindset
- Legally authorized to work in the United States
