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Ascendis Pharma, a global biopharmaceutical company, is seeking an experienced Specialist/Senior Specialist Pharmacometrician to join its growing Pharmacometrics Department in Hellerup, Denmark. The company applies its innovative TransCon® technology platform to develop therapies addressing unmet medical needs in endocrinology, rare disease, and oncology.
You will serve as a hands-on pharmacometrician combining scientific excellence with strategic thinking, providing broad ownership across programs. Reporting to the Senior Director and Head of Pharmacometrics, you will work both independently and collaboratively with cross-functional global teams, including in-house pharmacometricians, programmers, external consultants, and colleagues across translational and clinical development.
Key responsibilities include:
- Develop model-informed drug development strategies for translational and clinical-stage projects, ensuring optimal use of pharmacometric methods to inform trial and program design.
- Shape regulatory strategy and represent pharmacometrics in global health authority interactions.
- Inform dose selection, trial design, regulatory strategy, and lifecycle decisions through population PK/PD modeling, simulation, exposure–response analysis, and quantitative benefit–risk assessment.
- Translate quantitative results into clear, actionable recommendations for project teams, senior management, health authorities, and external partners.
- Plan, document, and report pharmacometric analyses in accordance with internal quality standards and global regulatory submission requirements.
- Strengthen departmental methods, standards, and capabilities through peer reviews, knowledge sharing, and continued development of the department's modeling and reporting environment.
You will gain exposure across translational and development stages, contributing to projects throughout the portfolio with broad visibility and influence. This is a fast-paced, dynamic role where quantitative methods directly inform trial design and evidence generation, particularly in rare disease populations. Travel: 5–10 days per year. Office location: Tuborg Boulevard 12, Hellerup, Denmark.
QUALIFICATIONS:
- PhD, MSc, or equivalent qualification in pharmacometrics, pharmaceutical sciences, pharmacokinetics, mathematics, engineering, or another relevant quantitative discipline.
- Relevant experience with PK/PD modeling and model-informed drug development.
- Hands-on experience with NONMEM and R applied to population PK/PD model development, simulation, and model-informed drug development.
- Strong programming skills and technical expertise to organize, perform, document, and report pharmacometric analyses to submission standard.
- Experience with translational and clinical-stage analyses, including population PK, PK/PD, exposure-response, dose selection, and trial-design questions.
- Strong team player, analytical mindset, and can-do attitude.
- Ability to communicate complex quantitative findings clearly and work effectively across disciplines.
- Combine strong quantitative background with biological and clinical understanding.
ADVANTAGEOUS:
- Industrial experience supporting regulatory interactions or submissions, including knowledge of FDA, EMA, and ICH expectations for pharmacometric analyses.
- Familiarity with LaTeX, Git, and reproducible reporting workflows.
- Experience applying machine learning, artificial intelligence, or automation to pharmacometric workflows.
