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Salary: USD 85,000 - 95,000 / annual
Arbor Biotechnologies is a clinical-stage gene editing company developing first-in-class genomic medicines for serious diseases including ALS and primary hyperoxaluria type 1. The company's unique breadth of gene editing technologies aims to unlock access to new gene targets and expand the therapeutic reach of genomic medicines.
In this role, you will be responsible for producing critical histology evidence that informs whether CNS gene editing programs advance toward the clinic. You'll run and quantify histology assays on rodent and non-human primate tissue that program teams use to make go/no-go decisions.
Key responsibilities include:
- Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue
- Process, stain, and image CNS tissue from rodent and non-human primate studies
- Quantify assay readouts using image analysis software such as HALO, QuPath, or ImageJ/Fiji
- Generate histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety
- Analyze and graph results in GraphPad Prism and summarize findings clearly for project scientists
- Plan histology endpoints and tissue readouts for in vivo studies with the study lead
- Present results in group meetings and cross-functional study discussions
- Troubleshoot assays, improve workflows, and maintain accurate experimental records and sample tracking
This role reports to the Senior Scientist, In Vivo Pharmacology and is on-site in Cambridge, typically 4–5 days per week.
REQUIREMENTS:
- Bachelor's degree in biology, neuroscience, pharmacology, or related field with 3+ years of industry experience, OR master's degree with 1+ year of industry experience
- Demonstrated experience developing, optimizing, and running IHC, IF, or ISH/RNAscope assays; automated staining platform experience preferred
- Experience working with CNS tissue from rodent models; non-human primate tissue experience preferred
- Proficiency in quantitative image analysis of CNS histology or ISH readouts using HALO, QuPath, ImageJ/Fiji, or comparable tools
- Ability to maintain detailed experimental records and present data to project teams
- Experience with gene therapy, gene editing, AAV, or CNS programs (preferred)
