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Salary: USD 110,000 - 160,000 / annual
ImmuneBridge is building next-generation cell therapies with a mission to enable high-quality cell therapies to be rapidly designed and manufactured at commercial scale and ultralow cost.
You will join as a hands-on process development scientist reporting to the Chief Technology Officer. Working in-person 5 days per week in San Francisco, you will own bioreactor work and run, optimize, and scale rocking-motion bioreactor processes for stem cell expansion and immune cell differentiation, helping translate the platform from bench toward clinical-scale manufacturing.
Key responsibilities:
**Bioreactor Operation:** Set up, run, and monitor rocking-motion (wave-type) bioreactor campaigns, including perfusion systems. Own critical parameters such as pH, dissolved oxygen, seeding density, and feed/perfusion rates.
**Process Development:** Design and execute experiments (including design of experiments where appropriate) to improve expansion, yield, and run-to-run consistency. Troubleshoot failed runs to root cause.
**Scale-up:** Translate plate- and flask-scale processes to multi-liter bioreactor scale and build scale-down models.
**Characterization:** Use cell counting and flow cytometry to track viability, identity, and phenotype. Analyze data and recommend next steps.
**Documentation & Tech Transfer:** Write protocols, run records, and development reports. Present data to leadership and support future tech transfer to CDMO partners.
**Requirements:**
- BS in bioengineering, chemical engineering, biochemical engineering, cell biology, immunology, or related field (advanced degrees welcome; level set by hands-on experience depth)
- Hands-on bioreactor experience with mammalian or primary cells, ideally rocking-motion systems (e.g., Cytiva WAVE/Xuri or similar), including developing or optimizing protocols
- Strong aseptic technique and cell culture skills; media/solution preparation expertise
- Sound experimental design and data analysis skills
- Good verbal and written communication skills
- Comfort with ambiguity and startup pace
- Ability to work on-site in San Francisco 5 days/week, primarily in the lab
- Attention to detail and excellent documentation skills
**Preferred qualifications:**
- Cell therapy process development experience (HSC, NK, T cell, or other immune cells)
- Perfusion or fed-batch process experience
- Flow cytometry experience
- Exposure to GMP, tech transfer, or CDMOs
- Prior startup experience
