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Pathos is an AI-driven drug development company that uses a proprietary Foundation Model and Foundry platform to inform portfolio decisions and accelerate clinical trial execution. The company operates with a lean, operator-focused structure: small teams of 3–5 subject matter experts, each commanding 30–50 AI agents to execute work that traditionally required dozens of people. Pathos has three clinical-stage oncology programs and a co-development partnership with a top-five pharma.
You will serve as Director, Clinical Operations Program Lead, reporting to the Chief Clinical Operations Officer. This is a foundational hire on the Clinical Operations team. Your role is to own the operational strategy and end-to-end execution of clinical programs—not by building a large operations team, but by acting as the operator who sets clinical operational direction and orchestrates AI agents to carry it out from study startup through database lock.
Key responsibilities include:
• Translating asset strategy into executable trial designs and operational plans.
• Orchestrating agentic systems to run day-to-day operations: tracking timelines and enrollment, monitoring site and vendor performance, surfacing risks, and drafting operational documentation.
• Setting program-level strategy while remaining comfortable with granular study details.
• Managing CRO and vendor accountability and performance.
• Making high-judgment calls that balance timelines, quality, and budget.
• Partnering closely with Clinical Development, Regulatory, Data Management, Biometrics, and Research.
• Ensuring trials start, enroll, and read out on time, on budget, and to quality.
• Delivering inspection-ready programs and clean, defensible clinical operations content for regulatory submissions.
Pathos operates with no middle management and no approval layers. You will be equally comfortable setting strategy and diving into detail. The company values operators who can specify what needs to happen, orchestrate AI agents at scale, and make compounding high-judgment decisions. Product velocity is measured in hours, not weeks.
Requirements:
• 10+ years of clinical operations experience, with demonstrated expertise in managing clinical trials from concept through close-out.
• Proven track record managing CROs and vendors, holding them accountable to clear standards.
• Deep knowledge of clinical trial operations, regulatory requirements, and GCP compliance.
• Experience with study startup, enrollment management, site monitoring, and database lock.
• Ability to translate clinical strategy into operational execution.
• Comfort with ambiguity and ability to make decisions with incomplete information.
• Preferred: Experience taking an oncology asset through pivotal or late-stage trials.
• Preferred: Track record building or scaling clinical operations infrastructure (SOPs, vendor frameworks, operating models) from early stage.
• Preferred: Technology-forward operator who has used AI, ML, or automation to run or accelerate clinical operations, and is energized by orchestrating agentic systems rather than growing headcount.
