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Salary: USD 106,000 - 123,000 / annual
Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines. The company uses proprietary molecular barcoding technology to screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at unprecedented scale.
You will own end-to-end planning, coordination, and execution of preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence. You will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, data collection, and delivery.
Key responsibilities include:
- Own end-to-end study coordination across multiple concurrent in vivo programs, from animal ordering and acclimation through dosing, bleeding, necropsy, tissue collection, and downstream handoff
- Develop and maintain detailed study plans, timelines, and execution schedules with clear accountability at every step
- Serve as primary point of contact between scientists, VIVO team members, vivarium staff, and external CROs
- Contribute to study design in collaboration with program leads, including dose selection, group sizes, timepoints, route of administration, and endpoint strategy
- Perform and oversee hands-on in vivo procedures including dosing (IV, SC, IP, PO), bleeds, perfusion, necropsy, and tissue collection
- Write, review, and refine study protocols and SOPs; contribute to protocol amendments as studies evolve
- Track and manage animal orders, reagent inventory, and study materials
- Identify bottlenecks and resource conflicts across the study portfolio and proactively surface solutions
- Mentor and train junior VIVO team members on in vivo techniques and study execution best practices
- Maintain accurate, organized records and data entry in Benchling and other platforms
- Coordinate with external CROs and vendors on outsourced study components
The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are comfortable building detailed study timelines and troubleshooting dosing days in real time, and you know when to push back on unrealistic timelines and when to find creative solutions.
REQUIREMENTS:
- Bachelor's or Master's degree in Biology, Pharmacology, Biomedical Science, or related field
- 5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment
- Demonstrated experience as a study director, study coordinator, or study lead — owning studies end-to-end with accountability for timelines and deliverables
- Deep proficiency with in vivo techniques: IV, SC, IP, and PO dosing; submandibular and cardiac bleeds; necropsy; tissue collection and processing across a broad panel
- Experience coordinating multiple concurrent studies across different programs and timelines
- Strong organizational skills and attention to detail
- Excellent cross-functional communication — comfortable working with scientists, RAs, vivarium staff, and leadership simultaneously
- Self-motivated and capable of operating independently with minimal supervision
- Genuine passion for science and for building something impactful
PREFERRED QUALIFICATIONS:
- Experience with humanized or disease mouse models
- Familiarity with NHP study coordination and CRO management
- Experience with downstream bioanalytical assays (ELISA, MSD, qPCR, western blot, flow cytometry, IHC, IF)
- Familiarity with histology, tissue sectioning, and confocal imaging workflows
- Experience with Benchling or similar LIMS platforms
- Exposure to protein therapeutics and other modalities
- Experience writing detailed study plans, SOPs, and IACUC protocol amendments
- Comfortable with data analysis tools including GraphPad Prism and Microsoft Office
