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Korro Bio is seeking an Associate Medical Director or Medical Director to provide medical leadership for clinical programs, with initial focus on KRRO-121, a Phase 1 program for hyperammonemia in urea cycle disorders and potential expansion into hepatic encephalopathy. This physician will report to the Vice President of Clinical Development and serve as the medical lead and medical monitor for first-in-human and early patient studies.
Key responsibilities include serving as medical monitor for studies from first-in-human single and multiple ascending dose cohorts through early patient studies; leading medical assessment of adverse events, serious adverse events, and laboratory abnormalities; serving on Safety Review Committees to support dose escalation decisions; authoring and reviewing clinical documents including protocols, informed consent forms, and regulatory submissions; contributing to clinical development plans and indication expansion strategy; building relationships with investigators, key opinion leaders, and patient advocacy organizations; and partnering across Clinical Operations, Biostatistics, Data Management, Clinical Pharmacology, Regulatory Affairs, Toxicology, and Drug Safety. The role includes reviewing emerging clinical data, maintaining knowledge of the scientific literature and treatment landscape, and contributing medical assessment to portfolio and business development evaluations. At the Medical Director level, the candidate will lead clinical strategy for an assigned program and represent Clinical Development in governance forums. Travel to investigational sites, meetings, and scientific congresses is expected, up to 25%.
The ideal candidate is a physician comfortable making and owning medical decisions in a small, fast-moving team and motivated to bring a new class of genetic medicines to patients.
REQUIREMENTS:
- MD or DO, or international equivalent, with completed residency training; board certification or eligibility in internal medicine, pediatrics, medical genetics, gastroenterology, hepatology, or related specialty preferred.
- Industry clinical development experience in biotechnology or pharmaceutical companies: minimum 2 years for Associate Medical Director; minimum 5 years for Medical Director, including prior accountability as medical monitor on early-phase studies and authorship of protocols and regulatory documents.
- Direct experience with first-in-human and early-phase clinical trials, including dose escalation, safety review committees, and dose-limiting toxicity assessment.
- Clinical or development experience in rare disease, inborn errors of metabolism, hepatology, or genetic medicines strongly preferred; familiarity with urea cycle disorders, hyperammonemia, or hepatic encephalopathy a plus.
- Experience with oligonucleotide, siRNA, or other RNA-targeted therapeutics, including GalNAc-conjugated agents, a plus.
- Working knowledge of ICH GCP and FDA and EMA requirements for early clinical development, including IND and CTA content; experience with early-phase studies outside the United States (Australia, Europe, Asia) a plus.
- Strong scientific writing and data interpretation skills, with ability to integrate safety, pharmacokinetic, and biomarker data and communicate conclusions to scientific, operational, and executive audiences.
- Hands-on, collaborative working style suited to a small company, with judgment to make and own medical decisions and flexibility to work across multiple programs, sites, and time zones.
