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Nautilus Biotechnology is developing a single-molecule protein analysis platform designed to democratize access to the proteome and accelerate drug development. The company is building a world-class team to pursue deep science and enable precision medicine.
In this Staff Scientist role, you will lead assay development and integration for new assay workflows on the single-molecule proteomics platform. Reporting to the program lead, you'll work at the intersection of science, engineering, and operations, collaborating with assay, probe development, engineering, and bioinformatics teams. You will own assay performance from first integration experiments through method transfer to operations.
Key responsibilities include:
- Lead design and development of robust assays and reagents with simple, elegant workflows
- Partner with the library prep team to confirm assay reagents work on the platform
- Define and develop control reagents to evaluate assay performance on the integrated system
- Develop workflows to remove reagents after each binding cycle while preserving proteins on the platform
- Design complex, information-rich experiments that provide decisive direction for the program
- Solve integration problems across detection, fluidics, optics, surface chemistry, reagents, and software
- Troubleshoot reagent and binding-cycle issues, driving root cause analysis and permanent corrective actions
- Lead failure analysis with engineering and bioinformatics teams to drive performance improvements
- Set assay performance metrics and acceptance criteria; make go/no-go calls based on data
- Analyze large datasets in Python, use bioinformatic pipelines, and translate results into R&D recommendations
You will be a seasoned assay scientist with a proven record of developing and integrating assays on complex instruments featuring integrated optics, fluidics, and surface chemistry. You excel at solving hard integration problems, leading teams through technical challenges, and making clear data-driven decisions.
Requirements:
- PhD in biochemistry, molecular biology, bioengineering, chemistry, or related field with 10+ years of industry experience; OR BS/MS with 15+ years in biotechnology or materials science
- Deep hands-on experience developing single-molecule assays and analysis techniques
- Demonstrated record of innovation in protein or molecular biology assays
- Hands-on experience handling proteins, including labeling, storage, and stability
- Track record of integrating assays on complex instruments with integrated optics, fluidics, and assay workflows
- Exceptional experimental design and data analysis skills, including multi-factor experiments
- Proficiency in Python or similar language for analyzing large datasets
- Track record of leading cross-functional technical work in fast-moving environments
Preferred qualifications:
- Experience with protein assays, affinity reagents, or immunoassays
- Experience with surface chemistry and immobilization on flow cells or arrays
- Experience with gentle elution, stripping, or surface regeneration methods
- Background in sequencing, proteomics, or other high-throughput platforms
- Experience transferring methods to operations or manufacturing
- Startup or early-stage product development experience
