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Senior Software Engineer

HeartFlow - San Francisco, CA, USA - In-office - posted 2026-10-07

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Salary: USD 180,000 - 215,000 / annual

HeartFlow is a publicly traded medical technology company (HTFL) pioneering AI-driven solutions for coronary artery disease diagnosis and management. The company's flagship product, HeartFlow FFR_CT Analysis, uses cutting-edge AI to provide 3D models of coronary arteries and assess blood flow impact. With international clearance and use across 750,000+ patients globally, HeartFlow is expanding its product pipeline and team. You will lead high-impact projects in a regulated medical environment, focusing on how real-world imaging conditions affect algorithm accuracy and reproducibility. This role bridges data science, product development, and clinical needs, requiring both technical depth and cross-functional collaboration. Key Responsibilities: - Build robust analytical pipelines and visualizations over population-scale data to characterize dataset distributions and algorithm performance across diverse patient populations - Translate findings about data variance and algorithm behavior into actionable requirements and algorithmic design recommendations - Formulate data annotation protocols for internal product development and FDA submissions - Collaborate cross-functionally with Research, Product, Clinical, and Engineering teams to transform clinical needs into cloud-based software solutions - Lead regulatory submission efforts, ensuring software components comply with relevant regulations by working closely with quality and regulatory teams - Lead technical projects from conception to deployment - Foster team growth through technical leadership and knowledge sharing - Diagnose and resolve complex technical issues across distributed systems, often under time constraints Requirements: - Master's or Ph.D. degree in Data Science, Computer Science, Statistics, Biomedical Engineering, or a related quantitative field - 5+ years of industry experience in Data Science, Biomedical Signal Analysis, or Biomedical Image Analysis (or 3+ years with a Ph.D.) - Expert proficiency in Python and statistical data analysis ecosystems (pandas, bokeh, statsmodels, or similar) - Proven experience working with large, complex, and messy datasets - Strong interpersonal communication skills; comfortable presenting results and recommendations to stakeholders - Team-oriented mindset with satisfaction in collaborating on difficult problems and providing mentorship - Proven experience with regulatory submissions and developing medical software in FDA, MDR, or similarly regulated environments - Experience in image processing, computer vision, or 3D computational geometry - Demonstrated experience with software development best practices: testing, CI/CD, and agile methodologies - Proficiency with orchestration tools (e.g., GitHub Actions) and Linux CLI navigation - Excellent troubleshooting and diagnostic skills across applications, networks, and cloud environments Desirable: - Experience collaborating directly with Product and Research teams on real-world medical challenges - Deep knowledge of statistical methods, image optimization techniques, and advanced visualization tools - Familiarity with HIPAA compliance and healthcare data security best practices - Open-source contributions or publications in relevant technical or clinical fields

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