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Typewriter Therapeutics, Inc. (Japan) is seeking an experienced pharmacology scientist to lead drug discovery efforts using the company's proprietary gene delivery technology. This role offers the opportunity to explore gene writing applications across multiple disease areas and establish novel therapeutic programs.
The successful candidate will oversee the execution of internal therapeutic programs from target identification through regulatory filings. Responsibilities include leading the development of the path to drug candidate nomination, conducting go/no-go decision-making based on target validation and proof-of-principle studies (in vitro and in vivo), and managing the work of direct reports as well as cross-functional team members. You will work collaboratively with global teams spanning molecular biology, cell biology, nonclinical, bioanalytical, CMC, and formulation disciplines.
Key responsibilities:
- Contribute to internal therapeutic strategy and lead program execution
- Design and oversee in vitro and in vivo pharmacology studies for drug candidate evaluation
- Manage direct reports and set team priorities in a matrixed structure
- Critically analyze data to inform program strategy and drug development decisions
- Oversee communication of study results to project teams and internal/external stakeholders in English and Japanese
- Support business development opportunity evaluation and patent filing
- Act as scientific mentor and role model
This position reports to the Senior Principal Scientist/Head of R&D Japan, Gene Therapy, and offers extensive learning opportunities in permanent gene insertion technology within a fast-paced, cross-functional startup environment.
QUALIFICATIONS:
- PhD in Molecular and Cell Biology or related field with 8+ years of relevant experience, OR BS/MS with 15+ years of relevant experience in life sciences
- Demonstrated proficiency in drug discovery research
- Expertise in one therapeutic modality required (gene editing or gene therapy); familiarity with other modalities a plus
- Expertise in designing and overseeing execution of in vitro/in vivo pharmacology studies in relevant cell types
- Expertise in designing and validating cell-based biochemical and enzymatic assays
- Knowledge of animal models of disease, particularly rare monogenic diseases
- Experience with molecular analysis of in vitro and in vivo gene insertion outcomes using next-generation sequencing, long-range sequencing, quantitative PCR, and RNA sequencing (a plus)
- Experience in IND filing (a plus)
- Experience managing direct reports and setting team priorities
- Ability to thrive in fast-moving, results-oriented startup environment
- Self-motivated, passionate, eager to continuously learn
- Flexible, cooperative, can-do attitude
